Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-06
1998-11-24
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
058407340
ABSTRACT:
A method of preventing photoaging and other types of sun damage by topically applying a composition containing Tempol is provided. Pharmaceutical compositions comprising Tempol for the prevention of photoaging and other types of sun damage are also provided.
REFERENCES:
CA 118: 142604, Emerit, 1992.
BA 95: 31379, Hahn et al, 1992.
Bernstein et al., "Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin", J. Invest. Dermatol. 1994, 103:182-186.
Bissett et al., "Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse", Photodermatol. Photoimmunol. Photomed. 1990, 7:56-62.
Chen et al., "Immunochemistry of Elastotic Material in Sun-Damaged Skin", J. Invest. Dermatol. 1986, 87:334-337.
Dahlback et al., "Fibrillin Immunoreactive Fibers Constitute a Unique Network in the Human Dermis: Immunohistochemical Comparison of the Distributions of Fibrillin, Vitronectin, Amyloid P Component, and Orcein Stainable Structures in Normal Skin and Elastosis", J. Invest. Dermatol. 1990, 94:284-291.
Frances, C. and Robert, L. "Elastin and Elastic Fibers in Normal and Pathologic Skin", Int. J. Dermatol. 1984, 23:166-179.
Goffman et al., "Topical Application of Nitroxide Protects Radiation-Induced Alopecia in Guinea Pigs", Int. J. Rad. Onc. Bio. Phys. 1992, 22:803-806.
Hsu-Wong et al., "Tissue-specific and Developmentally Regulated Expression of Human Elastin Promoter Activity in Transgenic Mice", J. Biol. Chem. 1994, 269:18072-18075.
Mera et al., "Elastic fibers in normal and sun-damaged skin: an Immunohistochemical study", Br. J. Dermatol. 1987, 117:21-27.
Mitchell et al., "Biologically Active Metal-Independent Superoxide Dismutase Mimics", Biochem. 1990, 29:2802-2807.
Mitchell et al., "Inhibition of Oxygen-Dependent Radiation-Induced Damage by the Nitroxide Superoxide Dismutase Mimic, Tempol", Arch. Biochem. Biophys. 1991, 289:62-70.
Miyachi Y., "Photoaging from an oxidative standpoint", J. Dermatol. Sci. 1995, 9:79-86.
Nilsson et al., "Inhibition of Lipid Peroxidation by Spin Labels", J. Biol. Chem. 1989, 264:11131-11135.
Samuni et al., "Superoxide Reaction with Nitroxide Spin-Adducts", Free Radical Biol. Med. 1989, 6:141-148.
Samuni et al., "A Novel Metal-free Low Molecular Weight Superoxide Dismutase Mimic", J. Biol. Chem. 1988, 263:17921-17924.
Warren et al., "Age, sunlight, and facial skin: A histologic and quantitative study", J. Am. Acad. Dermatol. 1991, 25:751-760.
Zimmerman et al., "Versican Is Expressed in the Proliferating Zone in the Epidermis and in Association with the Elastic Network of the Dermis", J. Cell. Biol. 1994, 124:817-825.
Cook Rebecca
Thomas Jefferson University
LandOfFree
Use of tempol in the prevention of photoaging does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of tempol in the prevention of photoaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of tempol in the prevention of photoaging will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1702546