Use of taxol-dependent cells to identify and isolate taxol-like

Details Use of taxol-dependent cells to identify and isolate taxol-like Use of taxol-dependent cells to identify and isolate taxol-like

1991-04-25

1994-08-23

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435 29, 435 30, 4352402, 436 63, 436 64, 4241951, C12Q 100, C12Q 104, C12Q 118, C12N 100

Patent

active

053407245

ABSTRACT:
The present invention relates to the use of taxol dependent cells, e.g. Tax 2-4 CHO cell line, as the basis of a screen for taxol or taxol-like compounds.

REFERENCES:
patent: 4960790 (1990-10-01), Stella et al.
patent: 5019504 (1991-05-01), Christen et al.
Parness, et al. Biochemical and Biophysical Research Communications. vol. 105, No. 3 pp. 1082-1089.
Mellado, et al. Biochemical and Biophysical Research Communications. vol. 124, No. 2, pp. 329-336.
Schibler, M. J., and Cabral F., "Taxol-dependent Mutants of Chinese Hamster Ovary Cells with Alterations in .alpha.- and .beta.-Tubulin," J. Cell Biol., 102, pp. 1522-1531 (1986).
Cabral, et al. Annals New York Academy of Sciences pp. 745-756 vol. 466. 1986.

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