Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1982-12-27
1985-11-05
Waltz, Thomas A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
260403, 260925, 260944, 260945, 514114, A61K 31685, A61K 3166, C07F 928
Patent
active
045514461
ABSTRACT:
Novel synthetic glyceryl-phosphorylcholine compounds are prepared having biological activity paralleling that of naturally generated platelet activating factor. In particular, the novel compounds of the present invention are useful to induce specific desensitization or tachyphylaxis of certain cells and tissues to platelet activating factor, rendering the cells or tissue unresponsive or hyporesponsive to subsequent platelet activating factor stimulation.
REFERENCES:
Chemical Abstracts, vol. 94, No. 13 (Mar. 30, 1981), p. 568, abstract No. 101,206t, Halonen, Marilyn et al., "Resp. & Cir. Alterations Induced by AGEPC, a Mediator of IgE Anaphylaxis in the Rabbit".
Chemical Abstracts, vol. 93, No. 7, (Aug. 18, 1980), pp. 84-85, abstract No. 61,491c, McManus, Linda M. et al., "Pathobio. of the I.V. Infusion of AGEPC, a Synthetic PAF, in the Rabbit.
C. R. Acad. Sc. Paris, t. 289 (Nov. 26, 1979), Serie D, No. 14, pp. 1037-1040, Benveniste et al., "Synthesis and Proposed Structure for Platelet Activating Factor".
Biochemical and Biophysical Research Communications, vol. 90, No. 4 (Oct. 29, 1979), pp. 1194-1200, Blank et al., "Antihypertensive Activity of an Alkyl Ether Analog of Phosphatidylcholine".
J. of Immunology, vol. 123, No. 4 (Oct. 1979), pp. 1847-1857, Pinckard et al., "Physicochemical & Functional Identity of Rabbit PAF Released in vivo During IgE Anaphylaxis with PAF released in vitro from IgE Sensitized Basophils".
J. of Biological Chemistry, vol. 254, No. 19 (Oct. 10, 1979), pp. 9355-9358, Demopoulos et al., "Platelet-Activating Factor".
Hanahan Donald J.
Pinckard R. Neal
Board of Regents , The University of Texas System
Waltz Thomas A.
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