Drug – bio-affecting and body treating compositions – Dentifrices
Reexamination Certificate
2002-01-22
2003-09-09
Rose, Shep K. (Department: 1614)
Drug, bio-affecting and body treating compositions
Dentifrices
C424S048000
Reexamination Certificate
active
06616915
ABSTRACT:
FIELD OF THE INVENTION
The invention resides in the area of mouth and teeth hygiene and concerns the use of preparations containing anionic and/or nonionic surfactants and selected glucans for producing oral hygiene and dental hygiene products as well as toothpastes with a defined composition.
The term oral hygiene and dental hygiene products is of one skilled in the art understood to be a liquid preparation, which as mouthwash disinfects the area of the mouth and throat, secondly are therewith understood paste or since a time back also tooth cleaning agents in the form of gels. These preparations are according to the requirements of their users—especially by small injuries in mouth and throat areas—not to lead to irritations. In the case of tooth care products the additional requirements are that the preparations must have a strong foam, a neutral taste and active cleaning abilities.
PRIOR ART
The term oral hygiene and dental hygiene products is of one skilled in the art understood to be a liquid preparation, which as mouthwash desinfects the area of the mouth and throut, secondly are therewith understood paste or since a time back also tooth cleaning agents in the form of gels. These preparations are according to the requirements of the users especially mucosa compatible, in order to—especially by small injuries in mouth and throut areas—not to lead to irritations. In the case of tooth care products the additional requirements are that the preparations must have a strong foam, a neutral taste and active cleaning abilities.
In this connection reference is for example made to the German patent application DE-A1 4406748 (Henkel), from which oral hygiene and dental hygiene products are known where the surfactant component mainly is made up of anionic surfactants of the type of monoglyceride sulphate and nonionic surfactants of the type of alkylglucosides. However, a drawback connected with these agents of the known art is that the compatibility with the oral mucosa, foam stability and cleaning efficiency is not completely satisfactory. Moreover, a special problem is to disperse abrasive ingredients in toothpastes and especially tooth gels, so that there will be no agglomeration or separation even at temperature storage.
In this connection reference is made to the international patent application WO 96/34608 (Colgate) where the use of &bgr;-glucans against xerostomia is known. The object of U.S. Pat. No. 3,931,398 (Colgate) is the subcutaneous administration of glucans in the vicinity of the oral cavity to combat caries. In the German patent application DE-A1 3621303 (FMC) gels based on &bgr;-1,3-glucans are suggested, which for example are made from agrobakterium and can be used in toothpastes. Finally, U.S. Pat. No. 4,340,673 (Merck) describes that special glucans with molecular weights above 500,000 can be used for combatting plaque.
Accordingly, the subject of the invention has consisted in alleviating the above mentioned disadvantages of the known art, by providing especially mouth-and tooth care products, especially toothpastes, which at the same time are caracterised by an optimal compatibility with the oral mucosa, foam stability and cleaning efficiency, immune stimulating and antimicrobial properties as well as especially a stable distribution of the abrasive bodies.
DESCRIPTION OF THE INVENTION
The object of the invention is the use of surfactant mixtures, containing
(a) anionic and/or nonionic surfactants and
(b) water soluble &bgr;-(1,3) glucans, which are substantially free of &bgr;-(1,6) linkages,
for the manufacture of oral hygiene and dental hygiene products, especially toothpastes
Surprisingly it was found that addition of only small amounts of water soluble &bgr;-(1,3) glucans, which are substantially free of unwanted (1,6) linkages, to known mouth or tooth care agents with a content of common anionic and/or nonionic surfactants not only improve their compatibility with the oral mucosa, but also supports the plaque removal, stabilize the foam and especially give a homogeneous and storage stable distribution of abrasive substances. The invention comprises the perception that the preparations further have antimicrobial effect and stimulate the immune system. By “agents” it is in connection with the invention therefore only meant toothpastes and toothgels, but also aqueous alcohol based mouthwash as well as chewing gums.
ANIONIC AND/OR NONIONIC SURFACTANTS
Typical examples of anionic surfactants are soaps, alkylbenzene sulphonates, alkane sulphonates, olefine sulphonates, alkylether sulphonates, glycerolether sulphonates, &agr;-methylester sulphonates, sulphofatty acids, alkyl sulphates, fatty alcohol ether sulphates, glycerol ether sulphates, mixed hydroxy ether sulphates, monoglyceride (ether) sulphates, fatty acid amide (ether) sulphates, mono- and dialkyl sulphosuccinates, mono- and dialkyl sulfosuccinamates, sulpho triglycerides, amido soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids such as for example acyl lactylate, acyl tartrate, acyl glutamate and acyl aspartate, alkyl oligoglucoside sulphate, protein fatty acid condensate (especially plant products based on wheat) and alkyl (ether) phosphate. If the anionic surfactants contain polyglycol ether chains, these could show a conventional, but preferably a narrow homologue distribution. Typical examples of nonionic surfactants are fatty alcohol polyglycol ethers, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty acid amide polyglycol ethers, fatty amino polyglycol ethers, alkoxylated triglycerides, mixed ethers, respectively mixed formals, possibly partially oxididized alk(en)yl oligoglycosides, respectively glucoronic acid derivatives, fatty acid-N-alkylglucamides, protein hydrolysates (especially plant products based on wheat), polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. Provided that the nonionic surfactants contain polyglycolether chains, these can show a conventional, but preferably a narrow distribution of homologues. Based on application technology reasons—especially compatibility with the oral mucosa and foaming ability—the use of alkyl sulphates, alkyl ether sulphates, monoglyceride (ether) sulphates, oleflne sulphonates and alkyl and/or alkenyl oligoglycosides as well as their mixtures is preferable, and they can be used as water containing pastes, preferably, however, as water free powders or granulates, which can be obtained for example by the Flash-Dryer or by the SKET procedure.
Alkyl Sulphates and Alkyl Ether Sulphates
Alkyl sulphates and alkyl ether sulphates, which are of interest as components (a), are known anionic surfactants, which in industrial scale are produced by sulphation of primary alcohols—preferably fatty alcohols or oxo alcohols—or their ethylene oxide addition products, and thereafter neutralisation of the resulting sulphuric acid half ester with bases. Preferably they have the following formula (I),
R
1
O(CH
2
CH
2
O)
n
SO
3
X (I)
where R
1
represents a linear or branched alkyl residue with 6 to 22 carbon atoms, n represents 0 or a number from 1 to 10 and X represents an alkali or alkaline earth metal, ammonium, alkyl ammonium, alkanol ammonium or glucammonium. Typical examples are the suphation products of caprone alcohol, capryl alcohol, 2-ethylhexyl alcohol, caprin alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, linolyl alcohol, linolenyl alcohol, elaeostearyl alcohol, arachyl alcohol, gadoleyl alcohol, behenyl alcohol, erucyl alcohol and brassidyl alcohol as well as their technal mixtures, which e.g. are obtained by the high pressure hydrogenation of methyl esters of technical quality based on fats and oils or aldehydes of Roelen's oxo synthesis and as fraction of monomers by the dimerization of unsaturated fatty alcohols, in the form of their sodium salts. Additional exam
Engstad Rolf E.
Fabry Bernd
Griesbach Ute
Wachter Rolf
Biotec ASA
Ladas & Parry
Rose Shep K.
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