Use of sulphonanilide derivatives to obtain a medicine for...

Details Use of sulphonanilide derivatives to obtain a medicine for... Use of sulphonanilide derivatives to obtain a medicine for...

2000-03-22

2001-06-19

Reamer, James H. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

active

06248786

ABSTRACT:

This application is a 371 of PCT/FR98/01928 Sep. 10, 1998.
The object of the present invention is the use of sulfonanilide derivatives to produce a medicinal product intended for the treatment of retrograde ejaculation or aspermia.
The compounds have the following general formula (I)
where
R1 is a hydrogen atom, a C
1-2
alkyl group, a C
1-2
fluoroalkyl group or a C
1-2
perfluoroalkyl group, and R
2
, R
3
and R
4
, which may be the same or different, all represent a hydrogen atom, a straight- or branched-chain C
1-4
alkyl group or a C
3-4
cycloalkyl group, preferably a hydrogen or a methyl and
R
5
is a hydrogen atom, a halogen such as fluorine or chlorine, a C
1-4
alkyl group or a straight- or branched-chain C
1-4
alkoxy group, preferably a methoxy or a halogen and more particularly a fluorine.
The compounds with the general formula (I) may include one or several asymmetric carbons. They can therefore exist in the form of enantiomers or diastereoisomers. These enantiomers, diastereoisomers and mixtures of them, including racemic mixtures, form part of the invention.
The compounds with the general formula (I) may take the form of the free base or addition salts with pharmaceutically acceptable acids, which are also part of the invention.
The compounds with the general formula (I) can be prepared according to the procedures described in European Patent EP 538469 or analog procedures known to specialists.


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