Use of sulfonylureas and other potassium channel regulators to t

Details Use of sulfonylureas and other potassium channel regulators to t Use of sulfonylureas and other potassium channel regulators to t

1992-09-28

1993-08-10

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142235, 514275, 514422, 514593, 514592, A61K 3154

Patent

active

052349225

ABSTRACT:
Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are disclosed. The CFTR chloride channel blocker is a sulfonylurea of the group consisting of tolbutamide, glibenclamide, and related analogs. The potassium channel opener is selected from the group consisting of diazoxide, lemakalim, and minoxidil sulfate.

REFERENCES:
patent: 5100647 (1992-03-01), Agus et al.

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