Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1989-04-20
1991-05-21
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 55, 514 57, 514 59, 435196, A61K 31715, A61K 31725
Patent
active
050175653
ABSTRACT:
This invention encompasses a method and compositions which inhibit pancreatic cholesterol esterase and triglyceride lipase and hence, lower cholesterol and triglycerides in the blood stream.
REFERENCES:
patent: 3148114 (1964-09-01), Fahrenbach et al.
patent: 3175942 (1965-03-01), Anderson et al.
patent: 3511910 (1970-05-01), Halleck
patent: 3627872 (1971-12-01), Parkinson
patent: 4066829 (1979-01-01), Nair et al.
patent: 4150110 (1979-04-01), Yoshida et al.
patent: 4160826 (1979-07-01), Fischetti
patent: 4223023 (1980-09-01), Furda
patent: 4436731 (1984-03-01), Maltz
patent: 4520017 (1985-05-01), Tunc
patent: 4602003 (1986-07-01), Malinow
patent: 4623539 (1986-11-01), Tunc
patent: 4727063 (1988-02-01), Naggi et al.
patent: 4883788 (1989-11-01), Day et al.
Jansen et al; Biochem. Biophys. Res. Commun. 92(1):53-59 1980.
Superko; Cardiovascular Reviews & Reports 6(11):1253-1254, 1257-1258 and 1263-1265 (1985).
Isaksson et al; Digestion 24:54-59 (1982).
Werner et al; Hepato.-Gastroenterol. 29:157-160 (1982.
Hoffman et al., Carbohydrate Polymers, "Studies on the Blood-Anticoagulant Activity of Sulphated Polysaccharides with Different Uronic Acid Content" (1982) 2:115-121.
Fernandez et al., Biochim. Biophys. Acta, "Effects of Tetrahydrolipstatin, a Lipase Inhibitor, on Absorption of Fat from the Interstine of the Rat" (1989) 1001:249-255.
Ogawa et al., Chem. Pharm. Bull., "Studies of Hypolipidemic Agents. I. Syntheses and Hypolipidemic Activities of 1-Substituted 2-Alkanone Derivatives" (1986) 34:1118-1127; "Studies on Hypolipidemic Agents. IV. Syntheses and Biological Acitivites of trans- and cis-2-(4-Alkylcyclohexyl)-2-oxoethyl Arenesulfonates" (1987) 35:32767-3283; "Studies on Hypolipidemic Agents. V. Synthesis and Esterase-Inhibitory Activity of 2-(1,4- and 4,4-Dialkylcyclohexyl)-2-oxoethyl Arenesulfonates" (1987) 35:4130-4136.
Morin et al., Biochim. Biophys. Acta, "Relative Specificities of Inhibition of Acid Cholesteryl Ester Hydrolase and Neutral Cholesteryl Ester Hydrolase in Ccultured Rabbit Aortic Smooth Muscle Cells by Esterastin and Cholesteryl Oleyl Ether" (1989) 1004:139-142.
Seethanathan et al., Molecular & Cellular Biochem., "Glycosaminoglycans from Ateroid and Bovine Duodenal Mucosa and Pancreas" (Sep. 30, 1975) 8; 177-183.
Hadvary P., et al, Int. J. Obesity, "Lipstatin and Tetrahydrolipstatin, Potent and Selective Inhibitors of Pancreatic Lipase" (1987) 11; Suppl. 2,21.
Proceedings of the Journal of Experimental Biology and Medicine, 116: 496 (Vahouny and Treadwell, 1964).
Archives of Biochemistry and Biophysica 168: 57-65 (Calame et al., 1975).
Biochemica et Biophysica Acta, 296: 94-104 (Van Den Bosch et al. (1973).
Biochemica et Biophysica Acta 486: 103-113 (Momsen and Brockman, 1977).
European Journal of Biochemistry 117: 457-460 (Guy et al. 1981).
Biochemical and Biophysical Research Communications 134: 386-392 (Sutton et al., 1986).
Arch. Int. Pharmacodyn. 144: 1-19 (Cook et al., 1963).
Proc. Natl. Acad. Sci. U.S.A. 85: 7438-7442 (Bosner, et al., 1988).
Carbohydrate Research 73: 332-336 (Larm et al., 1979).
Clinical Research 37: 366A (Bosner et al., 1989).
Am. J. Physiol. 206: 223-228 (Borja et al., 1964).
"Agents Used to Treat Hyperlipidemia", The AMA Drug Evaluations, 6th Ed., pp. 903-926.
Journal of the American Medical Association 253: 2080-2085 (1985).
Journal of the American Medical Association 253: 2087-2090 (Harlan and Stross, 1985).
Journal of the American Medical Association 253: 2091-2093 (Kronmal, 1985).
Journal of the American Medical Association 253: 2094-2095 (Rahimtoola, 1985).
Arch. Intern. Med., 148: 36-69 (1988).
American Journal of Surgery 113: 27-31 (Barnes et al. 1967).
Journal of Clinical Biochemical and Nutrition 2: 55-70 (Goto et al., 1987).
Lange, III Louis G.
Spilburg Curtis A.
Carson Nancy S.
Griffin Ronald W.
LandOfFree
Use of sulfated polysaccharides to inhibit pancreatic cholestero does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of sulfated polysaccharides to inhibit pancreatic cholestero, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of sulfated polysaccharides to inhibit pancreatic cholestero will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-238534