Use of substituted chromans, some of which are known, as medicam

Details Use of substituted chromans, some of which are known, as medicam Use of substituted chromans, some of which are known, as medicam

1994-06-01

1996-02-20

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514320, 546196, 546199, A61K 31445, C07D40514

Patent

active

054929180

ABSTRACT:
The present invention relates to the use of substituted chromans of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, for the production of medicaments, in particular as HIV protease-inhibiting agents, new active compounds and processes for their preparation.

REFERENCES:
patent: 4957928 (1990-09-01), Frostl
patent: 4977166 (1990-12-01), Hardy
patent: 4997836 (1991-03-01), Sugihara
patent: 5030639 (1991-07-01), Davis
patent: 5240943 (1993-08-01), Desai
patent: 5371094 (1994-12-01), Heine
Journal of Medicinal Chemistry, vol. 34, No. 8, Aug. 1991; Perspective, "HIV Protease: A Novel Chemotherapeutic Target for AIDS", J. R. Huff, pp. 2306-2314.
Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 6, pp. 541-546, 1992; "The Use of HIV-1 Protease Structure in Inhibitor Design", R. E. Babine et al.
J. Med. Chem., 1992, vol. 35, pp. 2525-2533; "A Series of Potent HIV-1 Protease Inhibitors Containing a Hydroxyethyl Secondary . . . ", T. J. Tucker et al.
The EMBO Journal, vol. 7, No. 6, pp. 1785-1791, 1988; "Partial purification and substrate analysis of bacterially-express HIV . . . ", J. Hansen et al.
Journal of Virological Methods, vol. 22, 1988, pates 309-317; "Antibodies to Human Cytomegalovirus Structural Polypeptides . . . ", M. P. Landini et al.

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