Use of substituted aminomethyl chromans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S222200, C514S277000, C514S332000, C514S336000, C514S279000, C514S449000, C514S456000, C514S646000, C514S727000, C514S751000, C514S753000, C514S759000

Reexamination Certificate

active

07618988

ABSTRACT:
Compounds of formula I in which R has a meaning as indicated in claim1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

REFERENCES:
patent: 5756521 (1998-05-01), Mewshaw
patent: 5767132 (1998-06-01), Bottcher et al.
N. Hewitt, et al., “Studies Comparing in vivo . . . Hepatocyte Cultures”,Drug Metabolism and Disposition, (2001), 29(7), 1042-1050.
R.E. Mewshaw, et al., “New Generation Dopaminergic . . . D2 Template”,Bioorganic&Medicinal Chemistry Letters, vol. 12, pp. 271-274 (2002).
A. Kuehler, et al., “Dyskinesien Bei. . . Parkinson Syndrome”,Nervenheilkunde,Schattauer, Stuttgart, vol. 19, No. 9, pp. 482-488 (2000).
S.L. Shefrin, et al., “Therapeutic Advances in Idiopathic Parkinsonism”,Expert Opinion on Investigational Drugs, vol. 8, No. 10, pp. 1565-1588 (Oct. 1999).

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