Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-10-09
1998-07-28
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 852, 424 937, 514 21, 530351, A61K 3818, C07K 1447
Patent
active
057863237
ABSTRACT:
Stem cell factor in combination with gp130 signaling supports proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells.
REFERENCES:
patent: 5004681 (1991-04-01), Boyse et al.
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5154921 (1992-10-01), Sayer et al.
patent: 5192553 (1993-03-01), Boyse et al.
patent: 5199942 (1993-04-01), Gillis
Nichols et al., Exp, Cell Res. 215 (1): 237-39 (Nov. 1994.
Yoshida et al. Mechanisms of Development, 45 (2): 163-71 (1994).
Muench et al., Exp. Hematol, 20: 339-49 (1992).
Han, Hokkaido Igaku Zasshi (Japan); 67 (5): 674-83 (Sep. 1992.
Nichols et al: Exp. Cell. Res; 215: 237-239, 1994.
Yoshida et al: Mechanisms of Development; 45: 163-171, 1994.
Muench et al: Exp. Hematol; 20: 339-349, 1992.
Flanagan et al., "The kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblast", Cell, 63:185-194 (1990).
Hirata et al., "Characterization of IL-6 Receptor Expression by Monoclonal and Polyclonal Antibodies", The Journal of Immunology, 143:2900-2906 (1989).
Hondo et al. "Human Soluble IL-6 Receptor: Its Detection and Enhanced Release by HIV Infection", The Journal of Immunology, 148:2175-2180 (1992).
Hondo et al., "Quantitative Analysis of Serum IL-6 and Its Correlation with Increased Levels of Serum IL-2R in HIV-Induced Diseases", The Journal of Immunology, 145:4059-4064 (1990).
Imai et al., "Interleukin-6 Supports Human Megakaryocytic Proliferation and Differentiation In Vitro", Blood, 78(8):1969-1974 (1991).
Iscove et al., "Net Increase of Pluripotential Hematopoietic Precursors in Suspension Culture in Response to IL-1 and IL-3", The Journal of Immunology, 142:2332-2337 (1989).
Koike et al., "Synergism of BSF-2/Interleukin 6 and Interleukin 3 on Development of Multipotential Hemopoietic Progenitors in Serum-Free Culture", J. Exp. Med., 168:879-890 (1988).
Koury and Bondurant, "Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erthroid Progenitor Cells", Science, 248:378-381 (1990).
Krantz, S.B., "Erthropoietin", Blood, 77(3):419-434 (1991).
Langley et al., "Soluble Stem Cell Factor in Human Serum", Blood, 81(3):656-660 (1993).
Liboi et al., "Erythropoietin Receptor Signals Both Proliferation and Erythroid-specific Differentiation", Proc. Natl. Acad. Sci., USA, 90:11351-11355 (1993).
Mayani and Lansdorp, "Thy-1 Expression Is Linked to Functional Properties of Primitive Hematopoietic Progenitor Cells from Human Umbilial Cord Blood", Blood, 83(9):2410-2417 (1994).
Nakahata and Ogawa, "Hemopoietic Colony-forming Cells in Umbilical Cord Blood with Extensive Capability to Generate Mono-and Multipotential Hemopoietic Progenitors", J. Clin. Invest., 70:1324-1328 (1982).
Nishi et al., "Induction of Mixed Erytroid-Megakaryocyte Colonies and Bipotential Blast Cell Colonies by Recombinant Human Erythropoietin in Serum-Free Culture", Blood, 76(7):1330-1335 (1990).
Okumura et al., "Changes in Cell Surface Antigen Expressions During Proliferation and Differentiation of Human Erythroid Progenitors", Blood, 80(3):642-650 (1992).
Saito et al., "Preparation of Monoclonal Antibodies Against the IL-6 Signal Transducer, gp130, That can Inhibit IL-6-Mediated Functions", Journal of Immunological Methods, 163:217-223 (1993).
Suzuki et al., "eurum Soluble Interleukin-6 Receptor in MRL/1pr Mice is Elevated with Age and Mediates the Interleukin-6 Signal", Eur. J. Immunol., 23:1078-1082 (1993).
Taga et al., "Functional Inhibition of Hematopoietic and Neurotrophic Cytokines by Blocking the Interleukin 6 Signal Transducer gp130", Proc. Natl. Acad. Sci. USA, 89:10998-11001 (1992).
Taga et al., "Interleukin-6 Triggers the Association of Its Receptor with a Possible Signal Transducer, gp130", Cell, 58:573-581 (1989).
Yasukawa et al., "Purification and Characterization of Soluble Human IL-6 Receptor Expressed in CHO Cells", J. Biochem., 108:673-676 (1990).
Yin et al., "Involvement of IL-6 Signal Transducer gp130 in IL-11-Mediated Signal Transduction", The Journal of Immunology, 151(5):2555-2561 (1993).
Yu et al., "Apoptosis and Hematopoiesis in Murine Fetal Liver", Blood, 81(2):373-384 (1993).
Zsebo et al., "Stem Cell Factor is Encoded at the S/Locus of the Mouse and is the Ligand for the c-kit Tyrosine Kinase Receptor", Cell, 63:213-224 (1990).
Achutamurthy Ponnathapura
Amgen Inc.
Crandall Craig A.
Levy Ron K.
Odre Steven M.
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