Use of staphylokinase for the preparation of a pharmaceutical co

Details Use of staphylokinase for the preparation of a pharmaceutical co Use of staphylokinase for the preparation of a pharmaceutical co

1993-07-14

1994-08-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 37547

Patent

active

053364953

ABSTRACT:
The present invention relates to the use of staphylokinase for the preparation of a pharmaceutical composition for treating arterial thrombosis, such as e.g. myocardial infarction. It is demonstrated that staphylokinase can be particularly useful as a thrombolytic agent for the lysis of platelet-rich clots. Furthermore it is demonstrated that staphylokinase, unlike streptokinase, does not induce antibody induction upon repeated administration.

REFERENCES:
Matsuo et al., Blood 76(5): 925-929 (1990).
Itoh, CA99:16311 (1983).
Abstract: JP-A-61 219 382, Sep. 29, 1986.
Abstract: JP-A-59 135 888, Aug. 4, 1984.
Friedman et al., "The Pathogenesis Of A Coronary Thrombus," vol. 48, No. 1, pp. 19-44 (1966).
Davies et al., "Plaque fissuring-the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina," Br. Heart F., vol. 53, pp. 363-373 (1985).
Jang et al., "Differential Sensitivity of Erythrocyte-Rich and Platelet-Rich Arterial Thrombi to Lysis With Recombinant Tissue-Type Plasminogen Activator," Circulation, vol. 79, No. 4, pp. 920-928 (1989).
Yasuda et al., "Lysis of Plasminogen Activator-Resistant Platelet-Rich Coronary Artery Thrombus With Combined Bolus Injection of Recombinant Tissue-Type Plasminogen Activator and Antiplatelet GPIIb/IIIa Antibody," JACC, vol. 16, No. 7, pp. 1728-1735 (1990).

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