Use of spiperone derivatives as immunosuppressant agents

Details Use of spiperone derivatives as immunosuppressant agents Use of spiperone derivatives as immunosuppressant agents

1991-12-27

1994-03-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514885, A61K 3144

Patent

active

052907830

ABSTRACT:
A method for suppressing an immune response in a mammal by treating the mammal with an effective amount of spiperone derivative that is without significant neuroleptic effect due to decreased binding to serotonin and/or dopamine receptors as compared with unmodified or uncomplexed spiperone, or due to topical application which maximizes local immunosuppression while limiting systemic absorption and neuroleptic effects. The spiperone derivatives are capable of inhibiting classic contact hypersensitivity reactions.

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Moerlein et al, "Effect of Lipophilicity on the In Vivo Localization of Radiolabelled Spiperone Analogues", Int. J. Nucl. Med. Biol. 12, 353-56 (1985).
Nakanishi et al, "Spirohydantoin Derivatives", Chemical Abstracts, 75, 437 (1971), Abstract 110315n.

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