Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2006-12-19
2006-12-19
Kwon, Brian (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C514S119000
Reexamination Certificate
active
07151093
ABSTRACT:
An anti fibrotic agent, comprising a sphingosine 1-phosphate (S1P) receptor agonist or sphingosine 1-phosphate (S1P) as an active ingredient. Since an S1P receptor agonist, particularly S1P, has activity of inhibiting fibrosis in various organs, it is useful in preventing and/or treating diseases caused by fibrosis in organs, such as pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, hepatic cirrhosis, chronic renal failure, renal glomerulosclerosis, etc.
REFERENCES:
patent: 4791105 (1988-12-01), Yamatsa et al.
patent: 5260288 (1993-11-01), Igarashi et al.
patent: 5374616 (1994-12-01), Spiegel et al.
patent: 5556843 (1996-09-01), Romeo et al.
patent: 5583160 (1996-12-01), Igarashi et al.
patent: 5627171 (1997-05-01), Park et al.
patent: 5663404 (1997-09-01), Igarashi et al.
patent: 5712262 (1998-01-01), Spiegel
patent: 5877167 (1999-03-01), Igarashi et al.
patent: 6210976 (2001-04-01), Sabbadini
patent: 6423508 (2002-07-01), Bergsma et al.
patent: WO 93/19760 (1993-10-01), None
“Medical Encylopeia:Idiopathic Pulmonary Fibrosis”, Medline Plus, 2004.
“Medical Encyclopedia: Chronic Renal Failure”, Medline Plus, 2005.
“Hepaptitis C”, DrugDigest, 2005.
“Attenuation of Bleomycin-Induced Pulmonary Fibrosis by a Catalytic Antioxidant Metalloporphyrin”, Oury et al., Am. J. Respir. Cell Mol. Biol., vol. 25, pp. 164-169, 2001.
“Attenuation of Bleomycin-Induced Lung Fibrosis in Rats by Mesna”, El-Medany et al., European Journal of Pharmacology, 509, 2005, pp. 61-70.
C. Gallois et al., Endothelin-1 Stimulates Sphingosine Kinase in Human Hepatic Stellate Cells. A Novel Role for Sphingosine-1-P as a Mediator of Growth Inhibition, Annals of the New York Academy of Sciences, (2000) vol. 905, pp. 311-314.
James R. Van Brocklyn, Dual Actions of Sphingosine-1-Phosphate: Extracellular Through the G1coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival, The Journal of Cell Biology, (1998) vol. 142, No. 1, pp. 229-240.
Ariarie Mallat et al., Growth Inhibitory Properties of Endothelin-1 in Activated Human Hepatic Stellate Cells: A Cyclic Adenosine Monophosphate-mediated Pathway, Journal of Clinical Investigations, (1996) vol. 98, No. 12, pp. 2770-2778.
Kishikawa Katsuya
Matsumoto Shigeru
Kwon Brian
Ono Pharmaceutical Co. Ltd.
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