Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1984-08-10
1989-02-14
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, A61K 4900
Patent
active
048045292
ABSTRACT:
The invention relates to specific relaxation agents for organs or pathologies, which can be used for modifying the contrasts in medical imaging by nuclear magnetic resonance.
These agents are constituted by a complex of a paramagnetic element having a biologically active ligand or a ligand coupled to a biologically active molecule and which is specific to an organ or pathology. Thus, they are selectively fixed to the organs and make it possible to modify the contrasts in imaging by nuclear magnetic resonance, due to the presence of the paramagnetic element, which modifies the relaxation times.
For example, when examining the kidney, the complex can be constituted by dimercaptosuccinate or gadolinium diethylene triaminopentaacetate, whilst gadolinium phytate is used in examinations of the liver.
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Chemical Abstracts, vol. 99, No. 7, Aug. 15, 1983, p. 232.
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Curtet et al., Proc. Natl. Acad. Sci. USA, vol. 83, (1986), pp. 4277-4281.
Bardy Andre
Conti Maria-Louisa
Courtieu Jacques
Grzyb Joelle
Mathieu Evelyne
Commissariat a l''Energie Atomique
Meller Michael N.
Raymond Richard L.
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