Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-09-19
1997-11-11
Schofer, Joseph L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
604 29, A61K 3173, A61K 31725
Patent
active
056864329
ABSTRACT:
The use of some glycosaminoglycans like sulodexide, low molecular weight heparin and low molecular weight dermatan sulfate and of the medicines by parenteral use that contain them in the treatment of patients suffering from chronic renal insufficiency subjected to peritoneal dialysis is described. The effectiveness of this use has been shown both by pharmacological studies carried out in nephrectomized rats to whom a peritoneal damage has been caused and by clinical studies carried out in patients suffering from chronic renal insufficiency subjected to CAPD and treated by intraperitoneal route (i.p.) with 2 ml vials of VESSEL DUE F.RTM. containing 50 mg of sulodexide. A significant increase of the peritoneal transports of urea and of creatinine joined to a significant decrease of the protein-loss in the peritoneal effluent has been observed. Significant changes of the ultrafiltration capacity and of haemorrhagic-coagulative complications have not been observed during the study.
REFERENCES:
patent: 5236910 (1993-08-01), Egidio et al.
patent: 5496807 (1996-03-01), Marchi et al.
Naito et al., "Blood Purification Method for High Risk Patient", Kidney and Dialysis, vol. 31, No. 1, pp. 187-190, 1991, ISSN: 0385-2156, Abstract Only.
Breborowicz et al., "Effects of Chondroitin Sulphate on Fluid and Solute Transport During Peritoneal Dialysis in Rats", Peritoneal Dialysis Int., 11(4), pp. 351-354, 1991, Abstract Only.
Breborowicz et al., "Chondroitin Sulphate and Peritoneal Permeability", Advances in Peritoneal Dialysis, vol. 8, pp. 11-14, 1992, Abstract Only.
Breborowicz et al., "The glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration During Peritoneal Dialysis", Nephron, vol. 67, No. 3, pp.346-350, 1994, Abstract Only.
Baggio Bruno
Bazzato Giorgio
Fracasso Agostino
Gambaro Giovanni
Marchi Egidio
Alfa Wassermann S.p.A.
Harrison Robert H.
Schofer Joseph L.
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