Use of sigma receptor antagonists to enhance the effects of anti

Details Use of sigma receptor antagonists to enhance the effects of anti Use of sigma receptor antagonists to enhance the effects of anti

1991-04-15

1993-07-27

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

052310990

ABSTRACT:
The invention relates to a method of treating psychosis in a mammal which comprises administering to the mammal an effective amount of a dopamine receptor antagonist antipsychotic and a sigma receptor antagonist having greater affinity for sigma receptors than for dopamine receptors, in an amount effective to selectively enhance the antipsychotic effects of the dopamine receptor antagonist relative to the adverse side effects of the dopamine receptor antagonist.

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patent: 4400383 (1983-08-01), Davidson et al.
patent: 4588728 (1986-05-01), Ferris
Ferris et al., J. Pharm. Pharmacol. 1982, 34:388.
Ferris et al., Life Sciences, 1986, 38:2329.
Ogren et al., Eur. J. Pharm. 1984, 102:439.
Snyder and Largent, J. Neuropsyc. 1989, 1:7.
Taylor and Dekleva, Drug Dev. Res. 1987, 112:65.

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