Use of sigma receptor antagonists for treatment of cocaine abuse

Details Use of sigma receptor antagonists for treatment of cocaine abuse Use of sigma receptor antagonists for treatment of cocaine abuse

1991-02-22

1993-01-19

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514306, 514314, 514318, 514323, 514326, 514415, 514419, A61K 31445, A61K 31505, A61K 3144, A61K 3121

Patent

active

051807297

ABSTRACT:
The invention relates to a method of treating cocaine abuse or addiction in a mammal which comprises administering to the mammal an effective amount of a sigma receptor antagonist lacking or having relatively weak dopamine receptor-blocking activity, to reduce the pharmacological effects of the cocaine.

REFERENCES:
Sharkey, J. et al, Eur J Pharmacol 149(1-2): 171-174 Mar. 1988.
Schlemmer et al., Soc. Neurosci. Abstr. 12(1):480 (1986).
Taylor et al., Drug Development Research 11:65-70 (1987).
Snyder et al., J. Neuropsychiatry 1:7-15 (1989).
Kosten, J. Nervous and Mental Disease 177:379-389 (1989).
Hock et al., Drug Development Research 6:301-311 (1985).
Ferris et al., Life Sciences 38:2329-2337 (1986).
Ogren et al., Eur. J. Pharmacology 102:459-474 (1984).
Kuhar et al. (1988) NIDA Monograph 88: 14-21.

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