Use of sigma receptor antagonists for treatment of amphetamine a

Details Use of sigma receptor antagonists for treatment of amphetamine a Use of sigma receptor antagonists for treatment of amphetamine a

1991-02-22

1992-11-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514306, 514314, 514318, 514323, 514326, 514415, 514419, A61K 31445, A61K 31505, A61K 3144, A61K 3140

Patent

active

051623412

ABSTRACT:
The invention relates to a method of treating drug abuse or addiction involving amphetamine or amphetamine-related drugs with pharmacological effects similar to amphetamine in a mammal which comprises administering to the mammal an effective amount, to reduce the pharmacological effects of the amphetamine or amphetamine-related drug, of certain piperidine sigma receptor antagonists.

REFERENCES:
Schlemmer et al., Soc. Neurosci. Abstr. 12(1):480 (1986).
Taylor et al., Drug Development Research 11:65-70 (1987).
Snyder et al., J. Neuropsychiatry 1:7-15 (1989).
Hock et al., Drug Development Research 6:301-311 (1985).
Ferris et al., Life Sciences 38:2329-2337 (1986).
Ogren et al., Eur. J. Pharmacology 102:459-474 (1984).

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