Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2004-11-23
2009-12-15
Navarro, Mark (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C536S023100
Reexamination Certificate
active
07632659
ABSTRACT:
The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include a variety of cell types, e.g. insect, reptile, fish, mammal and tumor cells. The suitable materials for transport include biochemicals such as reporter molecules, antibiotics, biopharmaceuticals and carbohydrates including polysaccharides, lipopolysaccharides, polynucleotides, such as DNA and RNA, and glycoproteins and proteins including antigens, enzymes, antibodies, receptors and hormones. In addition, Invaplex enhances the immune response to DNA vaccines and also can function by itself as a vaccine against shigellosis.
REFERENCES:
patent: 6245892 (2001-06-01), Oaks et al.
patent: 2001/0009957 (2001-07-01), Oaks et al.
patent: WO 00/23462 (2000-04-01), None
patent: WO 02/094190 (2002-11-01), None
“Development of invaplex as an in vitro transfection reagent (Ligocyte Pharmaceuticals),” Montana Department of Commerce, ′Online! Aug. 23, 2004, URL:http://www.commerce.state.mt.us.
“Internalization of invaplex isolated fromShigella flexneriand co-localization with intracellular organelles,” Kaminski at al.,Abstracts of the 104thGeneral Meeting of the American Society for Microbiology, vol. 1, May 23, 2004, p. B32.
“Delivery of proteins and nucleic acids into mammalian cells withShigella flexneriinvaplex,” Kaminski et al.,Abstracts of the 104thGeneral Meeting of the American Society for Microbiology, vol. 1, May 23, 2004, p. B32.
Kaminski Robert W.
Oaks Edwin V.
Arwine Elizabeth
Navarro Mark
The United States of America as represented by the Secretary of
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