Use of sesquiterpene lactones for treatment of severe inflammato

Details Use of sesquiterpene lactones for treatment of severe inflammato Use of sesquiterpene lactones for treatment of severe inflammato

1998-04-13

1999-05-18

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K31/34

Patent

active

059050896

ABSTRACT:
Sesquiterpene lactones are useful in suppressing the early proinflammatory cytokines, and in ameliorating septic shock and other severe inflammatory disorders. Sesquiterpene lactones with an .alpha.-methylene-.gamma.-lactone functional group suppress the expression of the inducible cyclooxygenase-2 and proinflammatory cytokines (Interleukin-1.alpha. and .beta., IL-1, and tumor necrosis factor-.alpha. (TNF.alpha.)) in mammalian macrophages stimulated with lipopolysaccharide. This suppression correlated with the inhibition of protein-tyrosine phosphorylation including the mitogen-activated protein kinases.

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