Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-11
2005-10-11
Shah, Mukund J. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S260100, C544S284000, C544S292000, C544S355000, C549S229000
Reexamination Certificate
active
06953800
ABSTRACT:
Described is the use in the treatment of either male or female sexual dysfunction of selective antagonists of the α1B-adrenergic receptor and the pharmaceutical compositions containing them as compounds capable of helping the sexual act avoiding at the same time excessive side effects due to acute hypotension.
REFERENCES:
patent: 5403842 (1995-04-01), Leonardi et al.
patent: 5474994 (1995-12-01), Leonardi et al.
patent: 5605897 (1997-02-01), Beasley, Jr. et al.
patent: 5700364 (1997-12-01), Rossen
patent: 0 611 248 (1994-08-01), None
patent: 0 611 248 (1994-08-01), None
patent: WO 95/25726 (1995-09-01), None
patent: WO 96/28142 (1996-09-01), None
patent: WO 97/11698 (1997-04-01), None
Sanger, F., et al; “DNA Sequencing With Chain-Terminating Inhibitors”;,Proc. Natl. Acad. Sci,vol. 74, No. 12; pp. 5463-5467 (Dec. 1977).
Schwinn, Debra A, et al; “Molecular Cloning and Expression of the cDNA for a Novel α1Adrenergic Receptor Subtype”;J. of Biological Chemistry;vol. 265, No. 14; pp. 8183-8189 (1990).
Sironi, Giorgio, et al., “Effects of Intracavernous Administration of Selective Antagonists of α-1Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs”,J. Pharmacology and Experimental Therapeutics,292(3):974-981 (2000).
Taddei, Carlo, et al; “Affinity of Different α-1Agonists and Antagonists for the α1Adrenoceptors of Rabbit and Rat Liver Membranes”;Life Sciences,vol. 53; pp. 177-181 (1993).
Testa, Rodolfo; “Characterization of α1-Adrenoceptor Subtypes In Prostate and Prostatic Urethra of Rat, Rabbit, Dog and Man”;Eur. J. of Pharmacology,vol. 249; pp. 307-315 (1993).
Testa, R., et al; “Pharmacological Characterization of the Uroselective Alpha-1 Antagonist Rec 15/2739 (SB 216469: Role of the Alpha-IL Adrenoceptor in Tissue Selectivity, Part II”;J. of Pharmacology and Experimental Therapeutics;vol. 281, No. 3; pp. 1284-1293 (1997).
Testa, R., et al; “REC 15/2739 (SB 216469):A Novel Prostate Selective α1-Adrenoceptor Antagonist”;Pharmacology Communications;vol. 6, Nos. 1-3; pp. 79-86 (1995).
Traish, Abdulmaged M., et al; “Identification of α1-Adrenergic Receptor Subtypes in Human Corpus Cavernosum Tissue and in Cultured Trabecular Smooth Muscle Cells”;Humana Press Inc.;vol. 5; pp. 145-157 (1995).
Traish, Abdulmaged M., et al; “A Heterogeneous Population of α1Adrenergic Receptors Mediates Contraction of Human Corpus Cavernosum Smooth Muscle To Norepinephrine”;J. of Urology;vol. 153; pp. 222-227 (Jan. 1995).
Vaidyanathan, S., et al., “Prolonged Penile Erection Association with Terazosin in a Cervical Spinal Cord Injury Patient”,Letters to the Editor, Regional Spinal Injuries Centre, District General Hospital, Southport, Merseyside, PR8 6PN, UK,36(11)805 (1998).
Véonneau-Longueville, F., et al; Expression of α1 Adrenoceptor Subtypes in Rat Corpus Cavernosum;Int. J. of Impotence Research;vol. 10; pp. 187-194 (1998).
Vieira, Jeffrey, et al., “The pUC Plasmids, An M13mp7-Derived System For Insertion Mutagenesis and Sequencing With Synthetic Universal Primers”,Elsevier Biomedical Press, Gene;vol. 19; pp. 259-268 (1982).
Yang-Feng, T.L., et al; “The Terminal Deoxynucleotidyltransferase Gene Is Located On Human Chromosome 10 (10q23→124) and On Mouse Chromosome 19”;Cytogenet Cell Genet,vol. 43; pp. 121-126 (1986).
Leonardi, A., et al., “Synthesis Pharmacological Evaluation and Structure-Activity Relationship and Quantitative Structure-Activity Relationship Studies on Novel Derivatives of 2,4-diamino-6,7-dimethoxyquinazoline α1-Adrenoceptor Anagonists”, J. Medicinal Chemistry, 42:427-437 (1999).
Leonardi, A., et al; “Pharmacological Characterization of the Uroselective Alpha-1 Antagonist Rec 15/2739 (SB 216469): Role of the Alpha-IL Adrenoceptor in Tissue Selectivity, Part 1”; vol. 281, No. 3;J. of Pharmacology and Experimental Therapeutics;pp. 1272-1283 (1997).
Lomasney, Jon W., et al; “Mammalian α1-Adrenergic Receptor: Purification and Characterization of the Native Receptor Ligand Binding Subunit”;J. of Biological Chemistry;vol. 261, No. 17; pp. 7710-7716 (1986).
Lomasney, Jon W.; et al; “Molecular Cloning and Expression of the cDNA for the α1A-Adrenergic Receptor:The Gene for Which is Located on Human Chromosome 5”;J. of Biological Chemistry;vol. 266, No. 10; pp. 6365-6369 (1991).
Maniatis, T. et al; “Rapid Isolation of Plasmid or Bacteriophage λ DNA”,Cold Spring Harbor Laboratory/Molecular Cloning, A Laboratory Manual;pp. 365-370 (1982).
Min, Kweonski, et al., “Functional Activity of Alpha-Adrenergic Receptors in Rabbit Vagina”, Abstract,Boston Female Sexual Function Conference—Oct. 26-27, 2000.
Montorsi, Francesco; “Pharmacological Management of Erectile Dysfunction”;Practical Therapeutics; Drugsvol. 50(3): pp. 465-479 (1995).
Muramatsu, Ikunobu, et al; “Functional Subclassification of Vascular α1-Adrenoceptors”;Pharmacology Communications;vol. 6; Nos. 1-3; pp. 23-28 (1995).
Oshita, Masafumi et al; “Pharmacological Characterization of Two Distinct α1-Adrenoceptor Subtypes In Rabbit Thoracic Aorta”,J. Pharmacol.vol. 108, pp. 1071-1076 (1993).
Park, K.; “Vasculogenic Female Sexual Dysfunction:The Hemodynamic Basis for Vaginal Engorgement Insufficiency and Clitoral Erectile Insufficiency”;Int. J. of Impotence Research;vol. 9; pp. 27-37 (1997).
Peterson, Craig, A.; Erectile Response To Transurethral Alprostadil, Prazosin and Alprostadil-Trazosin Combinations;J. of Urology;vol. 159; pp. 1523-1528 (May 1998).
Robert, JMH, et al; “Non-carboxylic Antiinflammatory Compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and Arylthiocarboxamides Acting as Brain Edema Inhibitors”;Eur. J. Med Chem;vol. 30: pp. 915-924 (1995).
Goepel, Mark, et al., “Characterization of α-Adrenoceptor Subtypes in the Corpus Cavernosum of Patients Undergoing Sex Change Surgery”; J. Urology, 162(5)1793-1799 (1999).
Giuliano, Francois et al; “Antierectile Role of the Sympathetic Nervous System In Rats”;J. of Urology;vol. 150, pp. 519-524 (Aug. 1993).
Harrison's Principles of Internal Medicine, 14th ed., p. 10, (1998).
Hatzichristou, DG; “Current Treatment and Future Perspectives For Erectile Dysfunction”;Int. J. of Impotence Research;vol. 10, Suppl. 1, pp. S3-S13 (1998).
Hayashida, Hideshi; “Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein”;Jpn. J. Pharmacol.;vol. 72, pp. 231-240 (1996).
Hedlund, H, et al; “Comparison of the Responses to Drugs Acting on Adrenoreceptors and Muscarinic Receptors in Human Isolated Corpus Cavernosum and Cavernous Artery”;J. Auton. Pharmcol.;vol. 5; pp. 81-88 (1985).
Hieble, Paul, J.; International Union of Pharmacology X. Recommendation for Nomenclature of α1-Adrenoceptors:Consensus Update;Pharmacological Reviews;vol. 47; No. 2; pp. 267-270, (c) 1995).
Holmquist, Fredrik, et al; Effects of the α1-Adrenoceptor Antagonist R-(—)-YM12617 on Isolated Human Penile Erectile Tissue and Vas Deferens;Eur.J. of Pharmacol.;vol. 186; pp. 87-93 (1990).
Israel, Manisha, “Viagra: The First Oral Treatment for Impotence”, Pharmaceutical Journal, Pharmaceutical Society, London, GB, 261:164-165 (1998).
Johnson, William S., et al; “An Approach To Taxodione Involving Biomimetic Polyene Cyclization Methodology”;Tetrahedron,vol. 38. No. 10; pp. 1397-1404 (1982).
Kawasaki, Ernest S., et al; “Detection of Gene Expression”; inPCR Technology: Principles and Applications for DNA Amplification,H.A. Erlich (ed.); pp. 89-97 (1989).
Kobilka, Brian K., et al; “cDNA For the Human β2-Adrenergic Receptor: A Protein With Multiple Membrane-Spanning Domains and Encoded By a Gene Whose
Leonardi Amedeo
Motta Gianni
Sironi Giorgio
Testa Rodolfo
Pharmaceutical Company
Recordati S.A. Chemical
Shah Mukund J.
Truong Tamthon N.
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