Use of ruthenium red as immunosuppressive agents

Details Use of ruthenium red as immunosuppressive agents Use of ruthenium red as immunosuppressive agents

1992-01-07

1993-08-24

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

424719, A01N 5916, A61K 3324

Patent

active

052386899

ABSTRACT:
This invention relates to the use of Ruthenium Red as an immunosuppressive agent to prevent or significantly reduce graft rejection in organ and bone marrow transplantation. Ruthenium Red can also be used as an immunosuppressant drug for T lymphocyte mediated autoimmune diseases. Furthermore, Ruthenium Red may be useful in alleviating psoriasis.

REFERENCES:
Dornand et al, Biochemical Pharmacology 36 (22) 3929-3936, 1987.
Broekemeier et al, J. Biological Chem 264 (14) 7826-7830, 1989.
Kapus et al., J. of Biological Chemistry, 265 (30): 18063-18066 (1990).
Missiaen et al., Biochimica et Biophysica Acta, 1023:449-454 (1990).
Tsuro et al., Gann, 71: 151-154 (1980).

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