Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1999-05-14
2000-10-31
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514570, A61K 31235
Patent
active
061403636
ABSTRACT:
The present invention relates to use of rosmarinic acid and/or derivatives thereof as immunosuppressive agents and/or as inhibitor of SH2 domain function. Disclosed in the present invention is that rosmarinic acid and derivatives thereof specifically inhibit the binding of ligand peptides to Lck SH2 domain, disturb the Lck-mediated signal transduction in T cells, also inhibit cytoline gene expression, and suppress immune responses in the transplanted tissue. These activities of rosmarinic acid and derivatives thereof support their applicability to treatment, prevention and/or diagnosis of graft rejection, GVHD, autoimmune diseases, inflammatory diseases, etc.
REFERENCES:
patent: 4329361 (1982-05-01), Zenk et al.
patent: 4354035 (1982-10-01), Christ et al.
patent: 4358442 (1982-11-01), Wirtz-Peitz et al.
Ahn Jong Sok
Ahn Soon Choul
Choi Young Bong
Hur Eun Mi
Jung Soo Il
Mogam Biotechnology Research Institute
Reamer James H.
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