Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-02-14
2006-02-14
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S006120, C514S04400A
Reexamination Certificate
active
06998254
ABSTRACT:
The subject of the present invention is the use of the ROR receptors and/or of their response element or alternatively of a functional equivalent thereof for the screening of substances having antiatherosclerotic properties. The invention also relates to the methods of screening substances having antiatherosclerotic properties using the ROR receptors and/or their response elements. The invention also relates to the use of the methods of screening according to the present invention in order to characterize, justify and claim the mechanism of action of substances having antiatherosclerotic properties using the ROR receptors and/or their response elements as well as their effects on apo C-III.
REFERENCES:
Accession No. X13367. Human DNA for apolipoprotein C-III 5′-flank, 1997.
Reue K et al. Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. J. Biol Chem., vol. 263, No. 14, pp. 6857-6864, 1988.
Bonhomme Yves
Raspé Eric
Chunduru Suryaprabha
Fredman Jeffrey
Merck Patent Gesellschaft
Millen White Zelano & Branigan P.C.
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