Use of RIPonucleases for treating parasitic and viral diseases

Details Use of RIPonucleases for treating parasitic and viral diseases Use of RIPonucleases for treating parasitic and viral diseases

1995-06-06

1997-11-04

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514 8, 514 12, 514895, 4241831, 530370, A61K 3846, A61K 3816, A61K 3800, A61K 39395

Patent

active

056836929

ABSTRACT:
A method of treating viral and protozoal infections using RIPonucleases is provided.

REFERENCES:
patent: 4795739 (1989-01-01), Lifson et al.
Cenini et al. Effect of ribosome-inactivating proteins on ribosomes from Tetrahymena pyriformis and Acathamoeba castellanii, Biochem. Biophys. Res. Commu. 148(2):521-526 Oct. 29, 1987.
Barbieri et al., "Ribosome-inactivating proteins from plants", Biochim. Biophys. Acta 1993, 1154, 237-282.
Brinkmann, U. and Pastan, I., "Immunotoxins against cancer", Biochim. Biophys. Acta 1994, 1198, 27-45.
Huang et al., "Anti-HIV plant proteins catalyze topological changes of DNA into inactive forms", BioFactors. 1992, 4, 37-41.
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Lee-Huang et al., "Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31", Proc. Natl. Acad. Sci. USA 1994, 91, 12208-12212.
Lee-Huang et al., "MAP 30: a new inhibitor of HIV-1 infection and replication", FEBS Let 1990, 272, 12-18.
Lee-Huang et al., "A new class of anti-HIV agents: GAP31, DAPs 30 and 32", FEBS Let 1991, 291, 139-144.
Ling et al., "Cleavage of supercoiled double-stranded DNA by several ribosome-inactivating proteins in vitro", FEBS Let 1994, 345, 143-146.
Li et al., "Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro", Nucleic Acids Res. 1991, 19, 6309-6312.
Rybak et al., "In vitro anti-tumor activity of the plant ribosome inactivating proteins MAP30 and GAP31", Int. J. Oncol. 1994, 5, 1171-1176.
Stirpe et al., "Gelonin, a New Inhibitor of Protein Synthesis, Nontoxic to Intact Cells", J. Biol. Chem. 1980, 255, 6947-6953.

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