Use of riluzole in the treating acoustic traumas

Details Use of riluzole in the treating acoustic traumas Use of riluzole in the treating acoustic traumas

2001-06-15

2003-12-09

Krass, Frederick (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S878000, C514S879000

Reexamination Certificate

active

06660757

ABSTRACT:

This application is a continuation of International application No. PCT/FR99/03108, filed Dec. 13, 1999; which claims the benefit of priority of French Patent Application No. 98/15,834, filed Dec. 15, 1998.
The present invention relates to the use of riluzole or one of its pharmaceutically acceptable salts in the prevention and/or treatment of acoustic traumas and, in particular, of deafness and of tinnitus.
Riluzole (2-amino-6-trifluoromethoxy-benzothiazole) is marketed for the treatment of amyotrophic lateral sclerosis. This compound is also useful as an anticonvulsant, an anxiolytic and a hypnotic (EP 50551), in the treatment of schizophrenia (EP 305276), in the treatment of sleep disorders and of depression (EP 305277), in the treatment of cerebrovascular disorders and as an anesthetic (EP 282971), in the treatment of spinal, cranial and craniospinal traumas (WO 94/13288), as a radio restorative (WO 94/15600), in the treatment of Parkinson's disease (WO 94/15601), in the treatment of neuro-AIDS (WO 94/20103), in the treatment of mitochondrial diseases (WO 95/19170). All of these references are herein incorporated by reference in their entirety.
It has now been found that riluzole or one of its pharmaceutically acceptable salts can also be used in the prevention and/or treatment of acoustic traumas and, especially, of tinnitus and of deafness and, in particular, of deafness caused by sound traumas and age-related deafness.


REFERENCES:
patent: 5624945 (1997-04-01), Bousseau et al.
patent: 5716961 (1998-02-01), Sands
patent: 50551 (1981-10-01), None
patent: 282971 (1988-03-01), None
patent: 305276 (1988-08-01), None
patent: 305277 (1988-08-01), None
patent: 9413288 (1994-06-01), None
patent: 9415600 (1994-07-01), None
patent: 9415601 (1994-07-01), None
patent: 9420103 (1994-09-01), None
patent: 9519170 (1995-07-01), None
Abraham Shulman, M.D.,International Tinnitus Journalvol. 3 (2), pp. 77-93 (1997).
Kretschmer, et al:Naunyn-Schmiedeberg's Arch Pharmacolvol. 358 (2), pp. 181-190 (1998).
Ehrenberger, et al:Acta Otolaryngolvol. 115, pp. 236-240 (1995).

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