Use of riluzole for the treatment of neuro-aids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31425

Patent

active

056249454

ABSTRACT:
The invention relates to the application of riluzole or the pharmaceutically acceptable salts of this compound in the treatment of neuro-AIDS.

REFERENCES:
patent: 4370338 (1983-01-01), Mizoule
patent: 4826860 (1989-05-01), Johnson et al.
patent: 4918090 (1990-04-01), Johnson et al.
A. Falkenbach et al., "Abnormalities in Cholesterol Metabolism Cause Peripheral Neuropathy and Dementia in AIDS--A Hypothesis", Medical Hypotheses, 33:57-61 (1990).
B. Navia et al., "The AIDS Dementia Complex: I. Clinical Features", Annals of Neurology, 19(6):517-524 (1986).
B. Navia et al., "The AIDS Dementia Complex: II. Neuropathology", Annals of Neurology, 19(6):525-535 (1986).
Atwood, Human Immunodeficiency Virus Type I Infection of the Brain, Clin. Microbiol. Rev. vol. 6, No. 4, pp. 339-366 (1993).
Portegies, Declining Incidence of Aids dementia complex after introduction of zidovudine treatment, BMJ vol. 299, pp. 819-821 (1989).
Lipton, Calcium Channel antagonists and HIV Coat Protein-medicated Neuronal Injury, Annals of Neurology, vol. 30, pp. 110-114 (1991).
Levi, HIV coat protein gp 120 inhibits the .beta.-adrenergic regulation of astroglial and microglial functions, Proc. Natl. Acad. Sci., USA, vol. 90, pp. 1541-1545 (1993).
Sundar, HIV glyoprotein gp 120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses, Proc. Natl. Acad. Sci., USA, vol. 88, pp. 11246-11250.
WHO Classification of Dementia, p. 148. No date.
Genis, Cytokines and Arachidonic Metabolites Produced during HIV-infected Macrophase-Astroglia Interactions: Implications for the Neuropathogenesis of HIV Disease, J. Experim. Med., vol. 176, pp. 1703-1718 (1992).
Debono, Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes, Eur. J. Pharm. vol. 235, pp. 283-289 (1993).
Lipton, Synergistic Effects of HIV Coat Protein and NMDA Receptor-Mediated Neurotoxicity, Neurotoxicity, Neuron, vol. 7, pp. 111-118 (1991).
Darnell et al., Molecular Cell Biology, Scientific American Books, 1985 Ed., pp. 208-217.
Steadman's Medical Dictionary, 26th ed., p. 1945. No Date.
WHO International Statistical Classification of Diseases and Related Health Problems, ICD-10 (1992).
Lipton, Models of neuronal injury in AIDS: another role for the NMDA Receptor, TINS, vol. 15, No. 3, pp. 75-79 (1992).
Dreyer, HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists, Science, vol. 248, pp. 364-367 (1990).
American Psychiatric Classification of Dementia, Diagnostic Criteria from DSM-11, pp. 88-91. No Date.
Annual Meeting of the American Epilepsy Society, Dec., vol. 33, Suppl. 3, p. 69 (1992) Koppel et al., "Antiepileptic Drug Treatment in Patients with AIDS".
Arch. Neurol. vol. 48, No. 12, 1991, pp. 1281-1284, Kieburtz et al. "Excitotoxicity and dopaminergic dysfunction in the Acquired Immunodeficiency Syndrome Dementia Complex".
J. Neurosci, Nov. 1989, vol. 9, No. 11 pp. 3720-3727, "Malgouris C et al" Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuroal damage in ischemic gerbils.
Curr. Opin. Neurol. Neurosurg. vol. 5, No. 4, 1992, pp. 508-513; B.S. Meldrum et al. "Excitatory amino acid receptors and disease."
Rapport de Recherche, dated Aug. 4, 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of riluzole for the treatment of neuro-aids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of riluzole for the treatment of neuro-aids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of riluzole for the treatment of neuro-aids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-706046

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.