Use of restriction endonucleases against viruses, including HIV

Details Use of restriction endonucleases against viruses, including HIV Use of restriction endonucleases against viruses, including HIV

1994-06-08

1996-06-04

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

435199, 424 946, 424 943, C12N 704, A61K 3846

Patent

active

055232329

ABSTRACT:
Restriction endonucleases are administered to a patient topically or internally to prevent or ameliorate viral infection. The endonucleases are also useful to treat products, such as blood and blood derived products, to eliminate viral transmission when the products are administered to a patient. In addition, the endonucleases may be used in the manner of a disinfectant to inactivate viral contamination on objects. The endonucleases are used in their native form, modified to provide decreased immunoreactivity or increased ability to target a site of infection or both, and alone or in combination with a suitable excipient. In addition to methods of treatment and disinfection, the invention provides related products, such as pharmaceutical compositions.

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