Use of reporter genes for retinoid receptor screening assays hav

Details Use of reporter genes for retinoid receptor screening assays hav Use of reporter genes for retinoid receptor screening assays hav

1994-12-21

1997-12-30

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 71, 435 76, 435 691, 536 241, C12N 1567, C12Q 102

Patent

active

057029148

ABSTRACT:
In accordance with the present invention, there are provided novel cotranscription factors that function to enhance mRNA transcription in cooperation with retinoid receptors. Also provided are novel DNA response elements, DNA constructs and expression vectors containing said constructs useful for providing cell-specific gene expression. Bioassays are also provided that are useful for evaluating whether a compound is a functional ligand (e.g., agonist or antagonist) for retinoid receptor protein(s), or functional engineered or modified forms thereof.

REFERENCES:
Simeone, A., et al. (1990) Nature 346:763-766.
Langston, A. W., et al. (1994) Curr. Opin. Genet. Dev. 4: 550-55.
Scott, M. P. (1993) Nucleic Acids Res. 21: 1687-88.
Jonk, L. J., et al. (1994) Dev. Biol. 161: 604-14.
Bouillet, P., et al. (1995) Dev. Biol. 170: 420-33.
Ogura, T., et al. (1995) Proc. Nat. Acad. Sci. USA 92: 387-91.
Ogura, T., et al. (1995) Proc. Nat. Acad. Sci. USA 92: 392-96.

Affiliated with

Also associated with

Rating

Use of reporter genes for retinoid receptor screening assays hav does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of reporter genes for retinoid receptor screening assays hav, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of reporter genes for retinoid receptor screening assays hav will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-201403