Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-06-23
1995-12-26
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, A61K 3702, C07K 740
Patent
active
054788072
ABSTRACT:
The invention concerns the use of relaxin or another compound capable of specific binding of a relaxin receptor in the heart in the cardiovascular therapy, and specifically in the treatment of acute and chronic heart failure or of a condition characterized by pathologically low heart rate. The invention further concerns the treatment of neurodegenerative diseases using relaxin or other compounds capable of selectively binding a relaxin receptor in the brain.
REFERENCES:
patent: 4656249 (1987-04-01), Trapear et al.
patent: 4758516 (1988-07-01), Hudson et al.
patent: 4835251 (1989-05-01), Burnier et al.
patent: 4871670 (1989-10-01), Hudson et al.
patent: 5023321 (1991-06-01), Hudson et al.
patent: 5166191 (1992-11-01), Cronin et al.
Osheroff, P. L., et al., Proc. Natl. Acad. Sci. USA 89: 2384-2388 (1992).
Kakouris, H. et al., The Lancet 339: 1076 (1992).
Ward et al., Biochem. Biophys. Res. Comm. 186(2): 999-1005 (1992).
Sherwood, D. D., The Physiology of Reproduction, Chaper 16 "Relaxin", Knobil, E. and Neill, J. et al. (eds.) Raven Press, Ltd. New York, 1988, pp. 585-673.
Isaacs et al., Nature 271, 278 (1978).
Weiss et al., Chem. Abstr. 88, 224 88:71076g (1978).
Bigazzi et al., Chem. Abstr. 95, 366 95:12753x (1981).
Hudson et al., Nature 301, 628 (1983).
Hudson et al., EMBO J. 3, 2333 (1984).
Tregear et al., Relaxin, Bryant-Greenwood, Niall and Greenwood (eds.), Elsevier, 1981, pp. 152-164.
Johnston et al., in Peptides: Structure and Function, Proc. Ninth Am. Peptide Symp., Deber, C. M. et al. (eds.), Pierce Chem. Co. 1985.
Tregear et al., in Biology of Relaxin and its Role in the Human, Bigazzi et al. (eds.) Elsevier N.Y., N.Y. 42-55 (1982).
O'Byrne et al., J. Clin. Endocr. and Metabol. 47, 1106 (1978).
Sherwood et al., Endocrinology 107, 691 (1980).
Bell et al., Obstet. Gynecol. 69, 585 (1987).
Stewart et al., J. Clin. Endo. Metab. 70, 1771 (1990).
Aoi et al., Proc. Soc. for Exp. Biol. and Med. 153, 13 (1976).
Chesley, C. C., Hypertensive Disorders in Pregnancy, Appleton Century-Crofts publ. 119-153 (1978).
Moutquin et al., J. Gyn. Obst. Biol. Rep. 11, 833 (1982).
Clapp, J. F., Am. Obstet. Gynecol. 152, 659 (1985).
Massicotte et al., Clin. and Exp. Hyper.-Hyper. in Pregnancy B5(2), 135 (1986).
Robson et al., Am. J. Physiol. 256, H1060 (1989).
Miller et al., J. Pharmacol. Exp. Ther. 120, 426 (1957).
Braddon, S. A., Endocrinology 102, 1291 (1978).
Porter et al., J. Endocr. 83, 18 (1979).
Sanborn et al., Endocrinology 106, 1210 (1980).
Judson et al., J. Endocr. 87, 153 (1980).
Nishikori et al., Endocrinology 111, 1743 (1982).
Nishikori et al., J. Biol. Chem. 258, 2468 (1983).
Del Mese et al., in "Biology of Relaxin and its Role in the Human", Bigazzi et al. (eds.), 291-293 (1983).
St-Louis, J. and Massicotte, G., Life Sciences 37, 1351 (1985).
O'Byrne et al., J. Physiol. 561, 49P (1985).
Bigazzi et al., Acta Endocrinol. 112, 296 (1986).
Jones, S. A. and Summerlee, A. J. S., J. Physiol. 381, 37P (1986).
O'Bryne et al., J. Endocr. 109, 393 (1986).
Cronin et al., Biochem. Biophys. Res. Comm. 148, 1246 (1987).
Jones, S. A. and Summerlee, A. J. S., J. Endocr. 114, 241 (1987).
Dayanithi et al., Nature 325, 813 (1987).
Massicotte et al., P.S.E.M.B. 190, 254 (1988).
Chen et al., Biol. Reprod. 39, 519 (1988).
Mumford et al., J. Endocrinol. 122, 747 (1989).
Ahokas et al., Am. J. Obstet. Gynecol. 161, 618 (1989).
Parry et al., J. Neuroendocrinol. 2, 53 (1990).
Parry et al., Endocrinol. 129, 47 (1991).
Kramer et al., In Vitro Cell. Dev. Biol. 26, 647 (1990).
Ward et al., Am. J. Physiol. 261, H206 (1991).
Casten et al., Angiology XI, 408 (1960).
Casten et al., J.A.M.A. 166, 319 (1958).
Ward et al., Genentech Reports No. 88-485-350-561 (1989).
Mercado-Simmen et al., J. Biol. Chem. 255, 3617 (1980).
Mercado-Simmen et al., Biology of Reproduction 26, 120 (1982).
Mercado-Simmen et al., Endocrin. 110, 220 (1982).
Osheroff, P. L., J. Biol. Chem. 265, 9396 (1990).
Osheroff, P. L. and Phillips, H. S., Proc. Natl. Acad. Sci. 88, 6413 (1991).
Schramm et al., Arzneim-Forsch. 33, 1268 (1983).
Evans et al., Pharmacologist 25, 550 (1983).
Evans et al., Drug Develop. Res. 9, 143 (1986).
Taylor et al., Ann. Rep. in Med. Chem. 22, 85 (1987).
Weishaar et al., Cardiovasc. Drugs and Ther. 3, 29 (1989).
Steffen et al., J. Cardiovasc. Res. 9, 143 (1986).
Steffen et al., New Cardiovascular Drugs, Raven Press, New York, p. 81 (1986).
Cronin Michael
Osheroff Phyllis L.
Thomas G. Roger
Ward David G.
Dreger Ginger R.
Genentech Inc.
Koh Choon
Wityshyn Michael G.
LandOfFree
Use of relaxin in the treatment of bradycardia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of relaxin in the treatment of bradycardia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of relaxin in the treatment of bradycardia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1369221