Use of radiolabeled peptide derived from crosslinked fibrin to l

Details Use of radiolabeled peptide derived from crosslinked fibrin to l Use of radiolabeled peptide derived from crosslinked fibrin to l

1981-04-02

1984-01-24

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424177, 260112B, 2601125R, A61K 4900, A61K 4300, C07G 700, C07C10352

Patent

active

044276460

ABSTRACT:
A method of locating thrombi in vivo comprising the steps of administering a radiolabeled peptide selected from the group consisting of Fragment E.sub.1 isolated from cross-linked fibrin, Fragment E.sub.2 isolated from crosslinked fibrin, and peptides having an amino acid sequence intermediate between Fragments E.sub.1 and E.sub.2 derived from crosslinked fibrin by plasmin digestion to a human or animal wherein the peptide is selectively incorporated or bound by forming a pre-formed thrombi and externally detecting the radiation emitted by the radiolabeled peptide. A composition containing the peptide used for locating thrombi is also disclosed.

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Kisiel et al., Biochem., 15 (1976) 4893-4900.
Niemann et al., Biochem. 19 (1980) 1576-1583.
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