Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp

Details Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp

1995-05-22

1998-04-28

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564308, A61K 31135

Patent

active

057445001

ABSTRACT:
The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

REFERENCES:
patent: 3201470 (1965-08-01), Huebner
patent: 3253037 (1966-05-01), Huebner
patent: 3513244 (1970-05-01), Gittos et al.
patent: 4826875 (1989-05-01), Chiesi
Tekes, et al. Effect of MAO inhibitors on the uptake and metabolism of dopamine in rat and human brain, Pol. J. Pharmacol. Pharm. (1988) 40:653-658.
Youdim, et al. in Handbook of Experimental Pharmacology vol. 90/I (1988) Chapter 3, Trendelenburg and Weiner, eds.
The Parkinson Study Group, New England J. Med. (1989) 321(20): 1364-1371.
The Parkinson Study Group, New England J. Med. (Jan. 21, 1993) 328(3): 176-183.
Riederer and Youdim, J. Neurochem. (1986) 46(5): 1359-1365.
Finberg and Youdim, British J. Pharmac. (Jun. 1985) 85 (2): 541-546.
Kabins and Gershon, Potential applications for monoamine oxidase B inhibitors Dementia (1990) 1: 323-348.
The Merck Index (Tenth ed. 1983) pp. 149, 248-249.

Affiliated with

Also associated with

Rating

Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and comp will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1532323