Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-21
1997-12-02
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514557, 514866, A61K 31385, A61K 3119
Patent
active
056936648
ABSTRACT:
The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone.
The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.
REFERENCES:
patent: 4678670 (1987-07-01), Tomic
Chemical Abstracts (Natraj et al.) ab. No. 495u.
Chemical Abstracts (Gandhi et al.) ab No. 161793c.
The Merck Index, Windholz et al. pp. 723 and 724 ab. No. 4866.
Biochem. Biophys. Res. Commun., Bd. 203, Nr. 1, 1994, pp. 99-104, T. Kawabata et al., "Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein".
Naunyn-Schmiedebergs Arch. Pharmacol, Bd. 349, Nr. supl., 1994, Seite r8, C. Bonaventura et al. "In Vitro Action of the enantiomers of alpha-lipoic acid".
Nervenarzt, Bd. 59, Nr. 1, 1988, pp. 36-44, J. Jorg et al., "Zur medikamentosen Behandlung der diabetischen polyneuropathie mit der alpha-liponsaure oder vitamin-b-praparaten"
Dtsch. Zschr. Verdau. Stoffwechselkr., Bd. 44, Nr. 4, 1984, pp. 173-180, J. Studt et al., "die diabetische autonome neuropathie des herzens und ihre behandlung mit thioctsaure"
Bisswanger Hans
Borbe Harald
Hettche Helmut
Klip Amira
Packer Lester
Asta Medica Aktiengesellschaft
Weddington Kevin E.
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