Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and m

Details Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and m Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and m

1997-06-19

1999-09-07

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514557, 514866, A61K 31385, A61K 3119

Patent

active

059488107

ABSTRACT:
The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance.

REFERENCES:
patent: 4678670 (1987-07-01), Tomic
Natraj et al. Chemical Abstracts (101) 495u, 1984.
Gandhi et al. Chemical Abstracts (104) 161793s, 1986.
Biochem. Biophys. Res. Commun., Bd. 203, Nr. 1, 1994, pp. 99-104, T. Kawabata et al., Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein.
Naunyn-Schmiedebergs Arch. Pharmacol. Bd. 349, Nr. supl., 1994, Seite r8, C. Bonaventura et al. "In Vitro Action of the enantiomers of alpha-lipoic acid".
Nervenarzt, Bd. 59, Nr. 1, 1988, pp. 36-44, J. Jorg et al., "Zur Medikamentosen Behandlung der diabetischen polyneuropathie mit der alpha-liponsaure oder vitamin-b-praparaten".
Dtsch. Zschr. Verdau. Stoffwechselkr., Bd. 44, Nr. 4, 1984, pp. 173-180, J. Studt et al., "die diabetische autonome neuropathie des herzens und ihre behandlung mit thioctsaure".
The Merck Index, Windholz, et al., pp. 723, 724, ab No. 4866 (1983).
S.S. Wagh et al.; Mode of Action of Lipoic Acid in Diabetes; Journal of Biosciences; Mar. 1987; pp. 59-74; vol. 11, No. 1-4.
Yuichiro J. Suzuki et al.; Lipoate Prevents Glucose-Induced Protein Modifications; Free Radiacl Res. Commun.; 1992; pp. 211-217, vol. 17; No. 3.

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