Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and m

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 3, 514458, 514557, A61K 31385, A61K 3828, A61K 31355, A61K 3119

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active

061178993

ABSTRACT:
The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone.
The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

REFERENCES:
patent: 4678670 (1987-07-01), Tomic
Chemical Abstracts (Natraj et al.) ab. No. 4956, 1984.
Chemical Abstracts (Gandhi et al.) ab No. 1617935, 1986.
The Merek Index, Windholz et al. pp. 723 and 724 ab No. 4866, 1983.
S.S. Wagh et al.; Mode of Action of Lipoic Acid in Diabetes; Journal of Biosciences; Mar. 1987; pp. 59-74; vol. 11, Nos. 1-4.
Yuichiro J. Suzuki et al.; Lipoate Prevents Glucose-Induced Protein Modifications; Free Radical Res. Commun.; 1992; pp. 211-217; vol. 17; No. 3.
T. Kawabata et al., "Alpha-Lipoate Can Protect Against Gylcation of Serum Albumin, but not Low Density Lipoprotein", Biochem. Biophys. Res. Commun., Bd. 203, Nr. 1, 1994, pp 99-104.
C. Bonaventura et al., "In Vitro Action of the Enantiomers of Alpha-Lipoic Acid", Naunyn-Schmiedebergs Arch. Pharmacol, Bd. 349, Nr. supl., 1994, Seite r8.
J. Jorg et al., "Zur Medikamentosen Behandlung Der Diabetischen Polyneuropathie Mit Der Alpha-Liponsaure Oder Vitamin-B-Praparaten", Nervenarzt, Bd. 59, Nr. 1, 1988, pp. 36-44.
J. Studt et al., "Die Diabetische Autonome Neuropathie Des Herzens Und Ihre Behandlung Mit Thioctsaure", Dtsch. Zschr. Verdau. Stoffwechselkr., Bd. 44, Nr. 4, 1984, pp. 173-180.
Natraj et al., Chemical Abstracts, Ab. No. 495U (1984)
Gandhi et al. Chemical Abstracts, Ab. No. 161793S (1986).
Windholz et al., The Merk Index, pp. 723-724, Ab. No, 4866 (1983).

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