Use of pyruvate to prevent neuronal degeneration associated with

Details Use of pyruvate to prevent neuronal degeneration associated with Use of pyruvate to prevent neuronal degeneration associated with

1993-09-20

1995-03-07

Henley, III, Raymond J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514557, A61K 3726, A61K 3119

Patent

active

053958225

ABSTRACT:
This invention discloses a method of using a salt of pyruvic acid (such as sodium pyruvate) to protect against neuronal degeneration due to ischemia (inadequate blood flow, which can be caused by stroke, cardiac arrest, or other events) or due to hypoxia, hypoglycemia, or cellular disorders which interfere with the energy metabolism of neurons. Treatment with pyruvate can be effective even when administered after the onset of an event that triggers neurodegeneration. A preferred mode of use involves co-administration of a pyruvate salt along with one or more agents that block NMDA and/or non-NMDA receptors, or with insulin or a thrombolytic agent.

REFERENCES:
patent: 5045454 (1991-09-01), Bertheussen
patent: 5192762 (1993-03-01), Gray et al.
patent: 5210098 (1993-05-01), Nath
Remington's Pharmaceutical Sciences (16th Edition) 1980 pp. 1468-1471 and 1490-1493.

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