Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-11-01
1986-07-08
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31505
Patent
active
045993394
ABSTRACT:
Trans-(.+-.)-2-Amino or substituted amino-4-permissibly-substituted 6-lower alkyl or allyl-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-)-stereoisomers and salts thereof, useful in treating anxiety, Parkinson's Syndrome, sexual dysfunction, depression, hypertension and elevated prolactin levels, and intermediates useful for the synthesis thereof.
REFERENCES:
patent: 4501890 (1985-02-01), Nichols et al.
patent: 4507478 (1985-03-01), Nichols et al.
patent: 4521421 (1985-06-01), Foreman
Costall and Naylor, Psychopharmacologia, 41, 57 (1975).
Bianchine et al., Dopaminergic Mechanisms, Fed. Proc., 37, 2434 (1978).
Post et al., Arch. Gen. Psychiatry, 35, 609 (1978).
C. Theohar et al., Current Therapeutic Research, 30, 830 (1981).
Randrup et al., Psychopharmacology, 53, 309 (1977).
Kornfeld Edmund C.
Nichols Cynthia L.
Barclay Bruce J.
Berch Mark L.
Eli Lilly and Company
Rivers Diana G.
Whale Arthur R.
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