Use of purified hematoporphyrin trimers in photodynamic therapy

Details Use of purified hematoporphyrin trimers in photodynamic therapy Use of purified hematoporphyrin trimers in photodynamic therapy

1989-04-26

1990-11-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540145, A61K 3140

Patent

active

049687158

ABSTRACT:
Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula ##STR1## wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.

REFERENCES:
patent: 4649151 (1987-03-01), Dougherty et al.
Scourides et al., Cancer Res (1987), 47:3439-3445.
Dougherty et al., Adv. Exp. Med. Biol. (1983) 160:3-13.
Kessel et al., Photo. Photo. Biol. (1987) 46:463-568.
Lipson et al., J. Natl. Cancer Inst. (1961) 26:1-8.
Morris, I. K. and Ward, D. A., Tetrahedron Letters (1988) 29(20): 2501-2504.

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