Use of pure histones H1 and H2A:H2B dimers in therapeutic method

Details Use of pure histones H1 and H2A:H2B dimers in therapeutic method Use of pure histones H1 and H2A:H2B dimers in therapeutic method

1989-04-03

1993-01-26

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530358, A61K 3700, A61K 3708, C07K 1300

Patent

active

051822571

ABSTRACT:
The invention relates to the use of pure histones H1, H2A, H2B, H2A:H2B, H3 as hormonal or hormon-like active substance for the preparation of pharmaceuticals for the immuno-therapy, for the therapy of endocrine disturbance and for cancer therapy. Instead of the histones also their evolutionary variable sections or at least one partial section of at least five aminoacid residues of at least one evolutionary variable histon section can be used.

REFERENCES:
patent: 4124700 (1978-11-01), Goldstein
patent: 4767714 (1988-08-01), Shalitin
patent: 4818763 (1989-04-01), Rusch et al.
patent: 4902505 (1990-02-01), Pardridge et al.
Matsukawa et al., J. Biochem., vol. 98, (1985), pp. 695-704.
Rudinger et al., Peptide Hormones, University Park Press, edited J. A. Parsons, pp. 1-7, Jun. 1976.

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