Use of protein C in the treatment of purpura fulminans

Details Use of protein C in the treatment of purpura fulminans Use of protein C in the treatment of purpura fulminans

1995-04-27

1996-08-27

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3848

Patent

active

055498930

ABSTRACT:
There is disclosed the use of protein C or activated protein C for preparing a drug useful for the maintenance and improvement of the microcirculation in patients suffering from circulatory disturbances, in particular with the proviso that the drug does not contain any immunoglobulin G.

REFERENCES:
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Musher, Hospital Practice 24(5): 71-98 (May 15, 1989).
Fourrier et al., Intensive Care Med 16(2):121-124 (1990) Abstract BA:31449.
Taylor et al. (Apr. 1988) Critical Care Medicine, "Characterization of the Response to E. coli in the Baboon".
Taylor et al. (Mar. 1987) J. Clin. Invest. 79: 918-925, "Protein C Prevents the Coagulopathic and Lethal Effects of E. coli Infusion in the Baboon".
Schwartz et al. (Nov. 1990) Blood Abstract No. 2070 76: 7069, "Successful Treatment of Purpura and Longterm Therapy with a Highly Purified Protein C Concentrate".
K ohler et al. (Aug. 1975) Nature 266: 495-498, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity".
D. Z. Chu, et al., "Purpura Fulminans", Medline Abstract No. 82157904, Am. J. Surg., Mar. 1982, 143(3), pp. 356-362.

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