Use of protease nexin-I to mediate wound healing

Details Use of protease nexin-I to mediate wound healing Use of protease nexin-I to mediate wound healing

1990-04-05

1992-05-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 37547

Patent

active

051126087

ABSTRACT:
A method of treating wound healing with a composition containing protease nexin-I (PN-I) is disclosed. Compositions comprised of PN-I uniformly dispersed throughout a pharmaceutically acceptable carrier are disclosed as are such compositions further comprising antibiotics. Occlusive wound dressings are taught which are comprised of a support surface having an absorbent area thereon which has PN-I absorbed thereon and which absorbent area is surrounded by a pressure sensitive adhesive strip for adhering the dressing to a surface surrounding the wound to be treated.

REFERENCES:
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4904469 (1990-02-01), Petereit et al.
patent: 5006252 (1991-04-01), Scott et al.
Meler et al., Letters to Nature, vol. 342 (1989), pp. 548-550.
Needels et al., Neuroscience, 18 (3) 1986, pp. 517-526.
Berg et al., J. Cell Biochem. Suppl., O (15 Part F) 1991 p. 192.
Gomez-Pinilla et al., Soc. Neurosci. Abstr., 16(2) 1990 p. 1346.
Rudge et al., J. of Neuroscience, 10 (11) 1990, pp. 3594-3603.
Ruppert et al., Matrix, 10(4) (1990) p. 246.
Scott et al., J. Biol Chem. (1985) 260(11):7029-7034.
Eaton et al., Chem. Abstracts (1984) 101(7):244 (abstract No. 50586v).
Gloor et al., Biol. Abstracts (1987) 83(7):792 (abstract No. 67719).
Erickson et al., Proc. Natl. Acad. Sci. (1985) 82:8710-8714.
Ny et al., Proc. Natl. Acad. Sci. (1986), 83:6776-6780.
Walsh, "Proteases in Biological Control" Reich et al., eds., (1975) Cold Spring Harbor Conferences on Cell Proliferation, vol. 2, New York, pp. 1-11.
Baker et al., Cell (1980) 21:37-45.
Low et al., Proc. Natl. Acad. Sci. (1981) 78(4):2340-2344.
Baker et al., The Receptors, vol. III (1985) Conn, P. M. ed., Academic Press, Chapter 5, pp. 153-172.
Scott et al., J. Biol. Chem. (1983) 258(17):10439-10444.
Guenther et al., EMBO Journal (1985) 4(8):1963-1966.
Barde et al., Nature (1978) 274:818.
Baker et al., J. Cell. Physiol. (1982) 112:291-297.
Low et al., Nature (1982) 298:476-478.
Lobb, Biochemistry (1988) 27(7):2572-2578.
Jones et al., Cancer Res. (1980) 40:3222-3227.
Bergman et al., Proc. Natl. Acad. Sci. (1986) 83:996-1000.
McGuire-Goldring et al., Arth. Rheum. (1984) 27:S24.
Monrad et al., Prog. Brain Res. (1983) 58:359-364.
Van Nostrand et al., Biochemistry (1988) 27:2176-2181.
McGrogan et al., Bio/Technology (1988) 6:172-177.

Affiliated with

Also associated with

Rating

Use of protease nexin-I to mediate wound healing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of protease nexin-I to mediate wound healing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of protease nexin-I to mediate wound healing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2425745