Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1992-01-16
1993-03-23
Naff, David M.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 941, 424443, 424445, 424446, 424447, 435176, A61K 37547, A61L 1500, A61F 1300, C12N 1114
Patent
active
051961962
ABSTRACT:
A method of treating wound healing with a composition containing protease nexin-I (PN-I) is disclosed. Compositions comprised of PN-I uniformly dispersed throughout a pharmaceutically acceptable carrier are disclosed as are such compositions further comprising antibiotics. Wound dressings are taught which are comprised of a support base having an absorbent area thereon which has PN-I absorbed thereon and which absorbent area is surrounded by a pressure sensitive adhesive strip for adhering the dressing to a surface surrounding the wound to be treated.
REFERENCES:
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4904469 (1990-02-01), Petereit et al.
patent: 5006252 (1991-04-01), Scott et al.
patent: 5112608 (1992-05-01), Scott et al.
Meier et al., Letters to Nature, vol. 342 (1989) pp. 548-550.
Needels et al., Neuroscience, 18(3) 1986, pp. 517-526.
Berg et al., J. Cell Biochem. Suppl., 0 (15 Part F) 1991, p. 192.
Gomez-Pinilla et al., Soc. Neurosci. Abstr. 16(2) 1990, p. 1346.
Rudge et al., J. of Neuroscience, 10(11) 1990, pp. 3594-3603.
Ruppert et al., Matrix, 10(4) 1990, p. 246.
Scott et al., J. Biol. Chem. (1985), 260 (11): pp. 7029-7034.
Eaton et al., Chem. Abstracts (1984) 101(7): 244.
Gloor et al., Biol. Abstracts (1987) 83(7): 792.
Erickson et al., Proc. Natl. Acad. Sci. (1985) 82: 8710-8714.
Ny et al., Proc. Natl. Acad. Sci. (1986) 83: 6776-6780.
Walsh, "Proteases in Biological Control", Reich et al., eds., (1975) Cold Spring Harbor Conf. on Cell Prol., vol. 2, pp. 1-11.
Baker et al., Cell (1980) 21: 37-45.
Low et al., Proc. Natl. Acad. Sci. (1981) 78 (4): 2340-2344.
Baker et al., The Receptors, vol. III (1985) Chapt. 5, pp. 153-172.
Scott et al., J. Biol. Chem. (1983) 258(17): 10439-10444.
Guenther et al., EMBO Journal (1985) 4(8): 1963-1966.
Barde et al., Nature (1978) 274: 818.
Baker et al., J. Cell Physiol. (1982) 112: 291-297.
Low et al., Nature (1982) 298: 476-478.
Lobb, Biochemistry (1988) 27 (7): 2572-2578.
Jones et al., Cancer Res. (1980) 40: 3222-3227.
Bergman et al., Proc. Natl. Acad. Sci. (1986) 83: 996-1000.
McGuire-Goldring et al., Arth. Rheum. (1984) 27: 524.
Monrad et al., Prog. Brain Res. (1983) 58: 359-364.
Van Nostrand et al., Biochemistry (1988) 27: 2176-2181.
McGrogan et al., Bio/Technology (1988) 6: 172-177.
Berg Richard A.
Scott Randy W.
Incyte Pharmaceuticals Inc.
Naff David M.
Weber Susan M.
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