Use of propylene oxide as an acid scavenger in peptide synthesis

Details Use of propylene oxide as an acid scavenger in peptide synthesis Use of propylene oxide as an acid scavenger in peptide synthesis

1995-11-30

1997-12-16

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530335, 530337, 530338, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

056986769

ABSTRACT:
A process of synthesizing a peptide using an alkylene oxide as an acid scavenger is provided. A process of the present invention can be used in a solid phase or solution phase synthetic process where peptide synthesis occurs by the sequential addition of N-.alpha.-amino-Boc-protected residues followed by acid deprotection of that N-.alpha.-amino protecting group and scavenging of the acid.

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