Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-12-12
2008-09-23
Bunner, Bridget E. (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
07427595
ABSTRACT:
The invention is directed to compositions and methods for wound healing and controlling inflammation that involve proepithelin, with or without secretory leukocyte protease inhibitor (SLPI).
REFERENCES:
patent: 5290762 (1994-03-01), Lezdey et al.
Abe, Tatsuya , et al., “Expression of the Secretory leukoprotease Inhibitor Gene in Epithelial Cells”,The Journal of Clinical Investigation, Inc., vol. 87, (Jun. 1991),2207-2215.
Ashcroft, Gillian S., et al., “Mice Lacking Smad3 show accelerated wound healing and an impaired local inflammatory response”,Nature Cell Biology, vol. 1, (1999),260-266.
Ashcroft, Gilliam S., et al., “Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing”,Nature Medicine, vol. 6, No. 10, (Oct. 2000), 1147-1153.
Baba, Tadashi , et al., “Acrogranin, an Acrosomal Cysteine-Rich Glycoprotein, Is the Precursor of the Growth-Modulating Peptides, Granulins, and epithelins and Is Expressed in Somatic as Well as Male Germ Cells”,Molecular Reproduction and Development 34, (1993),233-243.
Baggiolini, Marco , et al., “Interleukin-8, a chemotactic and inflammatory cytokine”,FEBS 11242, vol. 307, No. 1, (Jul. 1992),97-101.
Bateman, Andrew , et al., “Granulins, A Novel Class of Peptide From Leukocytes”,Biochemical and Biophysical Research Communications, vol. 173, No. 3., (Dec. 31, 1990),1161-1168.
Bateman, A. , et al., “Granulins: the structure and function of an emerging family of growth factors”,Journal of Endocrinology, 158, (1998),145-151.
Belcourt, Daniel R., et al., “Isolation and Primary Structure of the Three Major Forms of Granulin-like Peptides from Hematopoietic Tissues of a Teleost Fish (Cyprinus carpio)”,The Journal of Biological Chemistry, vol. 268, No. 13, (May 5, 1993),9230-9237.
Bhandari, Vijay , et al., “Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cystein-rich granulin domains”,Proc. Natl. Acad. Sci. USA, vol. 89, (Mar. 1992),1715-1719.
Carp, Harvey , et al., “Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants”,Experimental Lung Research, 1, (1980),225-237.
Caughey, George H., “Seriine Proteinases of Mast Cell and Leukocyte Granules (A League of Their Own)”,Am J. Respir Crit Care Med., vol. 150, (1994),S138-S142.
Chien, Cheng-Ting , et al., “The two-hybrid system: A method to identify and clone genes for protein that interact with a proteins of interest”,Proc. Natl. Acad. Sci. USA, vol. 88, (Nov. 1991),9578-9582.
Daniel, Rachel , et al., “Cellular Localization of Gene Expression for Progranulin”,The Journal of Histochemistry&Cytochemistry, vol. 48(7), (2000),999-1009.
Daiz-Cueto, Laura , et al., “Modulation of Mouse Preimplantation Embryo Development by Acrogranin (Epithelin/Granulin Precursor)”,Developmental Biology, 217, (2000),406-418.
Drew, Angela F., et al., “Wound-healing defects in mice lacking fibrinogen”,Blood, vol. 97, No. 12, (Jun. 15, 2001),3691-3698.
Eisenberg, Stephen P., et al., “Location of the Protease-inhibitory Region of Secretory Leukocyte Protease Inhibitor”,the Journal of Biological Chemistry, vol. 265, No. 14, (May 15, 1990),7976-7981.
Fuortes, Michele, et al., “Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF”,the Journal of Clinical Investigation, vol. 104, No. 3, (Aug. 1999),327-335.
Grutter, Markus G., et al., “The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine a-chymotrypsin”,The EMBO Journal, vol. 7, No. 2, (1988),345-351.
He, Zhiheng , et al., “Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and turmorigenesis”, J. Mol: Med., 81, (2003),600-612.
He, Zhiheng , et al., “Progranulin Gene Expression Regulates Epithelial Cell Growth and Promotes Tumor Growth in Vivo”,Cancer Research 59, (Jul. 1, 1999),3222-3229.
He, Zhiheng , et al., “Progranulin is a mediator of the wound response”,Nature Medicine, vol. 9, No. 2, (Feb. 2003),225-229.
Helmig, R. , et al., “Secretory leukocyte protease inhibitor in the cervical mucus and in the fetal membranes”,European Journal of Obstetrics&Gynecology and Reproductive Biology, 59, (1995),95-101.
Hong, Suk J., et al.,“Purification of Granulin-like Polypeptide from the Blood-Sucking Leech, Hirudo nipponia”,Protein Expression and Purification 16, (1999),340-346.
Hrabal, Richard , et al., “The hairpin stack fold, a novel protein architecutre for a new family of protein growth factors”,Nature Structural Biology, vol. 3, No. 9, (Sep. 1996),747-752.
Hunt, Thomas K., “Basic Principles of Wound Healing”,The Journal of Trauma, vol. 30, No. 12 Supplement,(Dec. 1990), S122-S128.
Hutchison, D. C., “The role of proteases and antiproteases in bronchial secretsions”,Eur. J. Respir. Dis, vol. 71, Suppl. 153,(1987),78-85.
Jin, Fenyu , et al., “Lipopolysaccharide-Related Stimuli Induce Expression of the Secretory Leukocyte Protease Inhibitor, a Macrophage-Derived Lipopolysaccharide Inhibitor”,Infection and Immunity, (Jun. 1998),2447-2452.
Jin, Fen-Yu , et al., “Secretory Leukocyte Protease Inhibitor: A Macrophage Product Inducted by and Antagonistic to Bacterial Lipopolysaccharide”,Cell, vol. 88, (Feb. 7, 1997),417-426.
Lee, Chul H., et al., “Distribution of Secretory Leukoprotease Inhibitor in the Human Nasal Airway”,Am. Rev. Respir. Dis., vol. 147, (1993),710-716.
Martin, Paul , “Wound Healing—Aiming for Perfect Skin Regeneration”,Science, vol. 276, (Apr. 4, 1997),75-81.
McElvaney, N. G., et al., “Modulation of Airway Inflammation in Cystic Fibrosis”,The Journal of Clinical Inivestigation, Inc., vol. 90, (Oct. 1992),1296-1301.
Mellet, Philippe , et al., “Mapping the Heparin-Binding Site of Mucus Proteinase Inhibitor”,Biochemistry, 34, (1995),2645-2652.
Nathan, Carl , et al., “Cytokine-induced Respiratory Burst of Human Neutrophils: Dependency on Extracellular Matrix Proteins and CD11/CD18 Integrins”,The Journal of Cell Biology, vol. 109, (Sep. 1989),1341-1349.
Ohlsson, Kjell , et al., “Secretory Leucocyte Protease Inhibitor in the Male Genital Trract: PSA-Induced Proteolytic Processing in Human Semen and Tissue Localization”,Journal of Andrology, vol. 16, No. 1, (Jan. 2, 1995),64-74.
Ong, C.H.P. , et al., “Progranulin (Granulin-epithelin precursor, PC-cell derived growth factor, Acrogranin) in proliferation and tumorigenesis”,Histol Histopathol, 18, (2003),1275-1288.
Park, Pyong W., et al., “Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters”,The Jouranl of Biological Chemistry, vol. 275, No. 39, (Sep. 29, 2000),29923-29926.
Plowman, Gregory D., et al., “The Epithelin Precursor Encodes Two Proteins with Opposing Activities on Epithelial Cell Growth”,The Journal of Biological Chemistry, vol. 267, No. 18, (Jun. 25, 1992),13073-13078.
Romer, John , et al., “Impaired Wound Healing in Mice with a Disrupted Plasminogen Gene”,Nature Medicine, vol. 2, No. 3, (Mar. 1996),287-292.
Sallenave, Jean-Michel , et al., “Secretory Leukocyte Proteinase Inhibitor is a Major Leukocyte Elastase Inhibitor in Human Neutrophils”,Journal of Leukocyte Biology, vol. 61, (Jun. 1997),695-702.
Shoyab, Mohammed , et al., “Epithelins 1 and 2: Isolation and characterization of two cysteine-rich growth-modulating proteins”,Proc. Natl. Acad. SciUSA, vol. 87, (Oct. 1990),7912-7916.
Singer, Adam J., et al., “Cutaneous Wound Healing”,The New England Journal of Medicine, (1999),738-7
Ding Aihao
Nathan Carl
Zhu Jing
Bunner Bridget E.
Cornell Research Foundation Inc.
Hamud Fozia M
Schwegman Lundberg & Woessner, P.A.
LandOfFree
Use of proepithelin to promote wound repair and reduce... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of proepithelin to promote wound repair and reduce..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of proepithelin to promote wound repair and reduce... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3984614