Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste u

Details Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste u Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste u

1986-05-14

1987-06-16

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514812, 514969, A61K 3144

Patent

active

046736794

ABSTRACT:
Aliphatic, aromatic, carbonate, carbamate, or sulfonate ester prodrugs of 3-hydroxymorphinans lack the bitter taste of the parent compounds and provide enhanced bioavailability of 3-hydroxymorphinans from buccal, nasal, and sublingual dosage forms.

REFERENCES:
patent: 4464378 (1984-08-01), Hussain
patent: 4582835 (1986-04-01), Lewis et al.

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