Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-07-17
1999-11-16
Clardy, S. Mark
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 436 63, 436512, 436518, 436528, 436529, 436530, 436535, 436161, 436547, 436548, 436811, G01N 3353, G01N 3348, G01N 33543
Patent
active
059855819
ABSTRACT:
The invention provides a method of diagnosing Alzheimer's disease. The method utilizes presenilin-1, whose level is found to be substantially decreased in Alzheimer's patients. Included in the invention are diagnostic kits for Alzheimer's disease and methods of screening for effective therapeutics for the disease. The invention also provides a method of studying the function and regulation of presenilin-1 in brain by the use of primate retinoblastoma cells.
REFERENCES:
Schellenberg et al., "Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14" Science, 258:668, (1992).
Alzheimer's Disease Collaborative Group, "The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families" Nature Genet., 11:219, (1995).
Sorbi et al., "Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease" Lancet, 346:439, (1995).
Van Broeckhoven, "Presenilins and Alzheimer disease" Nature Genet., 11:230, (1995).
Wasco et al., "Familial Alzheimer's chromosome 14 mutations" Nature Med., 1:848, (1995).
Sherrington et al., "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease" Nature, 375:754, (1995).
Levy-Lahad et al., "A Familial Alzheimer's Disease Locus on Chromosome I" Science, 269:970, (1995).
Levy-Lahad et al., "Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus" Science, 269:973, (1995).
Li et al., "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3" Proc. Natl. Acad. Sci. USA, 92:12180, (1995).
Rogaev et al., "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene" Nature, 376:775, (1995).
Kovacs et al., Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracelular membranes in mammalian cells Nature Med., 224:224, (1996).
Moussaoui et al., "Immunohistochemical analysis of presenilin-1 expression in the mouse brain" FEBS Letters, 383:219, (1996).
Pettegrew et al., "The Role of Membranes and Energetics in Alzheimer Disease" Alzheimers Disease, eds. R.D. Terry, R. Katzman, and K.L. Bick, Raven Press, NY, pp. 369-386 (1994).
Harrison, "S182: from worm sperm to Alzheimer's disease" The Lancet, 346:388, (1995).
Schwagerl et al., "Elevated Levels of the Endosomal--Lysosomal Proteinase Cathepsin D in Cerebrospinal Fluid in Alzheimer Disease" Journal of Neurochemistry, 64:443, (1995).
Cataldo Anne M.
Kao Benjamin H.
Mathews Paul M.
Nixon Ralph A.
Bieker-Brady Kristina
Clardy S. Mark
Hartley Michael G.
The McLean Hospital Corporation
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