Use of preparations of curcuma plants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514886, 514925, A61K 3105

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active

054017777

ABSTRACT:
The invention relates to the use of preparations of the plant Curcuma longa or other curcumin-containing plants, curcumin or curcumin derivatives for the prophylaxis and/or treatment of conditions associated with excessive formation of leucotrienes and/or prostaglandins and to the use of preparations of the plant Curcuma longa or other curcumin-containing plants, curcumin or curcumin derivatives for the production of medicaments for the prophylaxis and/or treatment of conditions associated with excessive formation of leucotrienes and/or prostaglandins.

REFERENCES:
M. Wichtl (1989) "Teedrogen" second edition, pp. 191-192, 297-298.
G. Madaus (1938) "Heilpflanzen", vol. II, pp. 1151-1156.
Ammon, et al. (1992) Curcumin: a potent inhibitor of leukotriene B.sub.4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL). Planta Med 58(2):226.
Flynn and Rafferty (1986) Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds. Prostaglandins Luekot. Med. 24(2-3):195-198.
Flynn and Rafferty (1986) Inhibition of 5-hydroxy-eicosatetraenoic acid (5-hete) formation in intact human neutrophils by naturally-occurring diarlyheptanoids:inhibitiory activities of curcumjinoids and yakuchinones. Prostaglandins Leukot. Med. 22(3):357-360.
Huang, et al. (1991) Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 51(3):813-819.
Wagner, et al. (1986) In vitro-Hemmung der Prostaglandin-Biosynthese durch etherische Ole und phenolische Verbindungen. Planta Med No. 3:184-187.
List and Horhammer (1973) Curcuma. "Hagers Handbuch der Pharmazeutischen Praxis." vol. 4, Springer Verlag, Berlin, pp. 380-389. (An English summary of this reference is provided.).
The Merck Index, 9th ed. 1926 p. 348 No. 2681.

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