Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-23
1999-12-14
Houtteman, Scott W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
530350, C12Q 168
Patent
active
06001573&
ABSTRACT:
A process is provided for using porphyrin or porphyrin derived compounds as universal labels for various assays and other quantification techniques without the need for a bridging agent to couple the label to the target particles. Particles which can be labeled include beads, microorganisms, cells, and molecules. The porphyrin label irreversibly attaches to target particles and afterwards can be detected and quantified by any number of ways, such as chemiluminometrically, fluorometrically or radiometrically in an amount which is proportional to the number of labeled particles.
REFERENCES:
patent: 3754868 (1973-08-01), Witz et al.
patent: 4176007 (1979-11-01), Jeffers et al.
patent: 4234681 (1980-11-01), DeLuca-McElroy
patent: 4375972 (1983-03-01), Forgione et al.
patent: 4485086 (1984-11-01), Wong
patent: 4577636 (1986-03-01), Spears
patent: 4614723 (1986-09-01), Schmidt et al.
patent: 4659676 (1987-04-01), Rhyne, Jr.
patent: 4672039 (1987-06-01), Lundblom
patent: 4803170 (1989-02-01), Stanton et al.
patent: 4933276 (1990-06-01), Baret
patent: 4994737 (1991-02-01), Stavrianopoulos
patent: 5108893 (1992-04-01), Baret
patent: 5242842 (1993-09-01), Sundrehagen
patent: 5306624 (1994-04-01), Roelant
patent: 5328824 (1994-07-01), Ward et al.
patent: 5340714 (1994-08-01), Katsilometes
patent: 5494793 (1996-02-01), Schindele et al.
patent: 5627028 (1997-05-01), Tai et al.
European Search Report, dated Mar. 17, 1997, from The Hague, by Examiner A. Wells, issued for Application No. EP 96 20 1674.
Adam, Yves et al, "Luminol and Isoluminol Chemiluminescence Reaction Catalyzed by Synthetic Water-Soluble Metalloporphyrins", New Journal of Chemistry, vol. 16, No. 4, pp. 525-528, Apr. 1992.
Ewetz, L. et al. "Factors Affecting the Specificity of the Luminol Reaction with Hematin Compounds", Analytical Biochemistry, vol. 71, No. 2, pp. 564-570, Apr. 1976.
Olsson, T. et al, "Catalytic Action and Destruction of Protohematin During Peroxide Dependent Luminol Chemiluminescence", Photochemistry and Photobiology, vol. 38, No. 2, pp.223-229, Aug. 1983.
Houtteman Scott W.
Packard Bioscience B.V.
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