Use of polysulphated alginate in cellular matrices

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

Reexamination Certificate

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Reexamination Certificate

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07988962

ABSTRACT:
The present invention describes an in vitro/ex vivo method for the cultivation of connective tissue cells or progenitor cells (e.g. chondrogenic cells) in matrix comprising polysulphated alginate. These cultivated cells can be used in the preparation of a medicament for the treatment or prevention of osteochondral defects. The invention also describes a matrix comprising polysulphated alginate and mammalian connective tissue cells or progenitor cells thereof.

REFERENCES:
patent: 5705177 (1998-01-01), Roufa et al.
patent: 5705178 (1998-01-01), Roufa et al.
patent: 5994325 (1999-11-01), Roufa et al.
patent: 6020326 (2000-02-01), Roufa et al.
patent: 6083930 (2000-07-01), Roufa et al.
patent: 6127348 (2000-10-01), Roufa et al.
patent: 6417173 (2002-07-01), Roufa et al.
patent: 6756362 (2004-06-01), Roufa et al.
patent: 2003/0109493 (2003-06-01), Maximillen et al.
patent: 2003/0161884 (2003-08-01), Rosenberg et al.
patent: 1 027 893 (2000-08-01), None
patent: WO 98/11141 (1998-03-01), None
Kavalkovich et al. , In vitro Cell. Dev. Biol.—Animal, 2002, vol. 38, p. 457-466.
Ronghua et al., Carbohydrate Polymers, Apr. 2003, vol. 52, p. 19-24.
Kawada et al. , Arch Dermatol Res, 1999, vol. 291, p. 542-547.
Rihova B., Advanced Drug Delivery Reviews, 1996, vol. 21, p. 157-176.
Verbruggen et al., J Rheumatol., 1999, vol. 26 , p. 1663-1671.
Hauselmann et al., American Journal of physiology, 1996, vol. 271, p. C742-C752.
Almqvist et al., “Culture of Chondrocytes in Alginate Surrounded by Fibrin Gel: Characteristics of the Cells Over a Period of Eight Weeks,” Annals, of Rheumatic Diseases 60: 781-790 (2001).
Schwelger et al., Polysaccharide Sulfates II Sulfuric Acid Esters of Glycuronans Having Various Degrees of Substitution 21:275-281 (1972).
Verbruggen et al., “Influence of Polysulfated Polysaccharides on Aggrecans Synthesized by Differentiated Human Articular Chondrocytes,” The Journal of Rheumatology 26:1663-1671 (1999).
International Search Report (PCT/BE2004/000171) (mailed Jun. 27, 2005).
Written Opinion of the International Searching Authority (PCT/BE2004/000171) (mailed Jun. 27, 2005).
Astrup, T. et al., “Polysaccharide Sulfuric Acids as Anticoagulants,”Acta Phys. Scand. 8: 215-226, 1944.
McPherson et al., “Articular Cartilage Injury,” Langer, R., Lanza, RP., & Vacanti, J. (Eds.) Principles of Tissue Engineering, Second Edition.Acad. Press697-709, 2000.
Sledge, “Microfracture Techniques in the Treatment of Osteochondral Injuries,”Clin. Sports Med. 20: 1-15, 2001.
Steadman et al., “Microfracture: Surgical Technique and Rehabilitation to Treat Chondral Defects,”Clin Ortho. and Related Research391S: S362-S369, 2001.
The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th ed. Budavari, S.; O'Neal, M.J.; Smith, A.; Heckelman, P.E.; Kinneary, J.F., Eds.; Merck & Co.: Whitehouse Station, NJ, p. 45, 1996.

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