Use of polyols for improving the introduction of genetic materia

Details Use of polyols for improving the introduction of genetic materia Use of polyols for improving the introduction of genetic materia

1994-09-30

1996-09-03

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352351, 4352402, 4353201, 514 44, 424 931, 424 932, 424426, 935 57, A01N 6300, C12N 500, C12N 1500

Patent

active

055523099

ABSTRACT:
A process for introducing an expression vehicle (e.g., plasmids, retroviral vectors, adenoviral vectors) into cells, which comprises contacting the cells with the expression vehicle and a polyol. The polyol may be a polyoxalkylene block copolymer, such as a polyoxypropylene-polyoxyethylene block copolymer. The use of the polyol provides for greater efficiency of transduction of the expression vehicle.

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